313657-76-0

Usage

Uses

Used in Pharmaceutical Synthesis:
(2R)-1-(3-CHLORO-2-PYRAZINYL)-2-METHYLPIPERAZINE is used as a key intermediate in the synthesis of various pharmaceuticals for its potential pharmacological or biochemical properties. Its unique structure allows it to be a valuable building block in the development of new drugs with specific therapeutic targets.
Used in Research and Development:
In the field of research and development, (2R)-1-(3-CHLORO-2-PYRAZINYL)-2-METHYLPIPERAZINE serves as a valuable compound for studying its properties and exploring its potential applications. Further research is needed to fully understand its characteristics and how it can be utilized in various industries, including pharmaceuticals, agrochemicals, and materials science.

InChI:InChI=1/C9H13ClN4/c1-7-6-11-4-5-14(7)9-8(10)12-2-3-13-9/h2-3,7,11H,4-6H2,1H3/t7-/m1/s1

Upstream product

• 126458-16-0 (R)-2-methylpiperazine, L-tartrate 
• 109-07-9 (RS)-2-methylpiperazine 
• 75336-86-6 (2R)-methylpiperazine 
• 531503-76-1 (R)-1-(3-chloro-2-pyrazinyl)-2-methyl-4-tritylpiperazine 
• 313657-75-9 (3R)-3-Methyl-1-Tritylpiperazine 

Downstream Products

• 639029-52-0 (2R)-1-(3-chloro-2-pyrazinyl)-2-methylpiperazine, hydrochloride 

Relevant academic research and scientific papers

NOVEL PROCESS

The present invention relates to a process for the preparation of compounds which are therapeutically active in the central nervous system. In one aspect, the invention relates to a process for the preparation of compounds of the general formula (I). The invention also relates to (2R)-1-(3-chloro-2-pyrazinyl)-2-methylpiperazine, hydrochloride and a process for preparing the same. Another object of the present invention is a compound of the formula (I). Another object of the present invention is a method for the treatment or prophylaxis of a serotonin-related disorder, comprising administering to a subject in need thereof an effective amount of the compound above; as well as the use of said compound to manufacture a medicament for the treatment of a serotonin-related disorder.

Synthesis of PNU-243922 labelled with 14C

The arylpiperazine PNU-243922 (1) has been labelled with 14C. A two-step sequence starting from the 14C labelled alcohol 6a led to radiochemically pure (> 98%) [14C]PNU-243922 with a specific activity of 546 MBq/mmol. Copyright

Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases

Compounds of the general formula (I): wherein the variables are as defined in the specification are useful for the prophylaxis or treatment of serotonin-related, especially 5-HT2receptor-related, diseases in human beings or animals, particularly diseases related to the 5-HT2creceptor, especially diseases such as eating disorders, memory disorders, schizophrenia, mood disorders, anxiety disorders, pain, sexual dysfunctionions, and urinary disorders.