31382-98-6

Upstream product

• 39996-57-1 N-amino mesitylenesulfonate salt of isoquinoline 
• 98-88-4 benzoyl chloride 
• 119-65-3 isoquinoline 
• 17508-17-7 O-(2,4-dinitrophenyl)hydroxylamine 
• 40339-95-5 2-aminoisoquinolinium iodide 
• 613-94-5 benzoic acid hydrazide 
• 38846-64-9 2-ethynylbenzaldehyde 
• 75586-29-7 2-ethynylbenzaldehyde benzoylhydrazone 
• 25705-34-4 2-(2-oxoethyl)benzaldehyde 

Downstream Products

• 30237-78-6 2,4,5-triphenyl-1,3-oxazin-6-one 
• 84802-67-5 (2-Hydroxy-1,3-diphenyl-pyridazino[6,1-a]isoquinolin-4-yl)-phenyl-methanone 
• 1005135-67-0 2-phenyl-N-benzoyliminoqisouinolinium ylide 
• 61001-36-3 2-phenyl-pyrazolo<5,1-a>isoquinoline 
• 1337985-01-9 2-cyclohexenylpyrazolo[5,1-a]isoquinoline 
• 42046-29-7 N-(3, 4-dihydroisoquinolin-2-(1H)-yl)benzamide 
• 1612154-16-1 C₁₉H₁₄N₂O₂ 
• 128368-41-2 3-Benzoylpyrazolo<5,1-a>isoquinoline 
• 33538-11-3 1‐cyclohexylisoquinoline 
• 1009-14-9 phenyl butyl ketone 
• 157069-84-6 N-(1-oxoisoquinolin-2(1H)-yl)benzamide 
• 1591802-91-3 (1,2-bis(phenylsulfonyl)-1,10b-dihydropyrazolo[5,1-a]isoquinolin-3(2H)-yl)(phenyl)methanone 
• 1425512-64-6 C₃₅H₃₈N₂O₅ 
• 1425512-63-5 C₃₁H₃₀N₂O₅ 

Relevant academic research and scientific papers

Construction of indazolo[3,2-: A] isoquinolines via [3 + 2] cycloaddition of benzynes

A [3 + 2] annulation protocol for the construction of N-substituted indazolo[3,2-a]isoquinolines starting from benzynes and C,N-cyclic azomethine imines was developed. A diverse range of highly functionalized products indazolo[3,2-a]isoquinolines featuring an indazole scaffold can be easily accessed via a one-step reaction under mild conditions, and they show good anti-proliferative activity on cancer cells.

Copper-Catalyzed Cross-Dehydrogenative Coupling of N-Iminoquinolinium Ylides with Secondary Amines

The copper-catalyzed cross-dehydrogenative coupling of N-iminoquinolinium ylides with secondary amines led to ortho-amino-substituted quinoline derivatives with high levels of regioselectivity in good yields. This direct C–H bond amination transformation employs CuI as the catalyst without the use of a ligand, external oxidant, or base. The reaction is operationally simple and can be conducted under mild conditions. The N-benzoyl directing group can be removed without any additional steps.

Benzoyl peroxide promoted radical ortho-alkylation of nitrogen heteroaromatics with simple alkanes and alcohols

A catalytic amount of benzoyl peroxide (BPO)-initiated cross-dehydrogenative coupling reaction of N-iminopyridine ylides with simple alkanes and alcohols leads to the corresponding 2-alkylpyridines with high regioselectivity in moderate to good yields without an additional reduction step to remove the activated group. A catalytic amount of benzoyl peroxide (BPO)-initiated cross-dehydrogenative coupling reaction of N-iminopyridine ylides with simple alkanes and alcohols has been developed. The strategy allowed convenient access to various 2-alkylpyridines in moderate to good yields without an additional reduction step to remove the activated group.

N-AMINOTETRAHYDROISOQUINOLINES AS ANTI-CANCER AGENTS

The compounds herein disclosed are tetrahydroisoquinoline analogs that have modifications on the phenyl rings by introducing groups with various electronic properties. These derivatives of tetrahydroisoquinoline have been shown to have anti-proliferative

Synthesis of 2- and 2,3-substituted Pyrazolo[1,5- a ]pyridines: Scope and mechanistic considerations of a domino direct alkynylation and cyclization of n -iminopyridinium ylides using alkenyl bromides, alkenyl iodides, and alkynes

Direct functionalization and tandem processes have both received considerable recent interest due to their cost and time efficiency. Herein we report the synthesis of difficult to obtain 2-substituted pyrazolo[1,5-a] pyridines through a tandem palladium-catalyzed/silver-mediated elimination/direct functionalization/cyclization reaction involving N-benzoyliminopyridinium ylides. As such, these biologically important molecules are prepared in an efficient, high-yielding manner, only requiring a two-step sequence from pyridine. Aryl-substituted alkenyl bromides and iodides are effective ylide coupling partners. Mechanistic studies led to the use of terminal alkynes, which extended the scope of the reaction to include alkyl substitution on the unsaturated reactive site. The optimization, scope, and mechanistic considerations of the process are discussed.

Highly efficient synthesis of o-(2,4-dinitrophenyl)hydroxylamine. Application to the synthesis of substituted N-benzoyliminopyridinium ylides

An efficient two-step synthesis of O-(2,4-dinitrophenyl)hydroxylamine is described along with a comparison of its aminating efficiency with O-mesitylenesulfonylhydroxylamine (MSH). It was used in an expedient N-amination/benzoylation procedure involving various substituted pyridines, leading to polysubstituted N-benzoyliminopyridinium ylides, and the scope of its amination power was studied.

The Reactions of 2-Alkynylbenzaldehydes with Hydrazides: a Route to Isoquinoline N-Imines

Sulphonyl- and acyl-hydrazones of 2-ethynylbenzaldehyde cyclise in the presence of base to give isoquinoline N-imines in moderate yield.The suggested mechanism involves primapy formation of the hydrazone anion followed by nucleophilic attack on the alkyne bond, either by anionic nitrogen to give an unstable 3H-2,3-benzodiazepine which rearranges to the isoquinoline N-imine, or by the neutral imine nitrogen to give the isoquinoline system directly.Attempts to extend the reaction to the semicarbazone and 2,4-dinitrophenylhydrazone were not successful.