31402-70-7Relevant academic research and scientific papers
Electrophilically activated nitroalkanes in synthesis of 3,4-dihydroquinozalines
Aksenov, Alexander V.,Aksenov, Dmitrii A.,Aksenov, Nicolai A.,Grishin, Igor Yu.,Malyuga, Vladimir V.,Nobi, Mezvah A.,Rubin, Michael
, (2021/08/03)
Nitroalkanes activated with polyphosphoric acid serve as efficient electrophiles in reactions with various nucleophilic amines. Strategically placed second functionality allows for the design of annulation reactions enabling preparation of various heterocycles. This strategy was employed to develop an innovative synthetic approach towards 3,4-dihydroquinazolines from readily available 2-(aminomethyl)anilines.
A single step procedure for synthesis of 2,4- and 2,3,4-substituted 3,4-dihydroquinazolines
Suri, K. A.,Satti, N. K.,Mahajan, Babita,Suri, O. P.,Dhar, K. L.
, p. 1171 - 1172 (2007/10/02)
Substituted 3,4-dihydroquinazolines have been synthesized in 80-85percent yields by interaction of N-acylated o-aminoacetophenone/o-aminobenzophenone with formamide or N-methylformamide in 85percent formic acid.
