6011-26-3

Usage

InChI:InChI=1/C15H13NO2/c1-11(17)13-9-5-6-10-14(13)16-15(18)12-7-3-2-4-8-12/h2-10H,1H3,(H,16,18)

Upstream product

• 700-46-9 4-methylquinazoline 
• 98-88-4 benzoyl chloride 
• 39608-24-7 3-hydroperoxy-3-methyl-2-phenyl-3H-indole 
• 412027-57-7 5-methyl-2-phenyl-1,5-dihydro-2H-2,5-epoxido-benzo[e][1,2,4]dioxazepine 
• 141-78-6 ethyl acetate 
• 104014-46-2 1-<2-(Benzylamino)phenyl>ethanon 
• 1885-29-6 anthranilic acid nitrile 
• 19226-36-9 3-phenyl-5H-1,4,2-dioxazol-5-one 
• 495-18-1 Benzohydroxamic acid 
• 2142-68-9 1-(2-chlorophenyl)ethanone 
• 55-21-0 benzamide 
• 106012-41-3 N-[2-(1-methylethenyl)phenyl]benzamide 
• 67-64-1 acetone 
• 98-86-2 acetophenone 

Downstream Products

• 10257-92-8 2-phenyl-3-methyl-1H-indole 
• 33768-44-4 1-(2'-Benzamidophenyl)ethanol 
• 146774-76-7 N-[2-(2,2,2-Trichloro-acetyl)-phenyl]-benzimidoyl chloride 
• 31402-70-7 4-methyl-2-phenyl-3,4-dihydroquinazoline 
• 78987-16-3 2'-Ethylbenzanilide 
• 1144-20-3 2-phenyl-4-quinolinol 
• 59411-03-9 N-(2-Acetyl-phenyl)-N-methyl-benzamide 
• 17182-60-4 N-methyl-2-phenylquinolin-4(1H)-one 
• 83-34-1 3-Methylindole 
• 57826-37-6 (3-methyl-1H-indol-1-yl)(phenyl)methanone 
• 14802-18-7 2-phenyl-1H-quinolin-4-one 
• 1392323-24-8 C₁₆H₁₄BrNO 
• 106012-41-3 N-[2-(1-methylethenyl)phenyl]benzamide 
• 1452815-49-4 (4-nitrophenyl)(2-phenylquinazolin-4-yl)methanone 

Relevant academic research and scientific papers

A Fluorination/Aryl Migration/Cyclization Cascade for the Metal-Free Synthesis of Fluoro-Benzoxazepines

Fluorinated organic molecules are of high interest for many applications across chemical and medical disciplines. Efficient methods for the synthesis of such compounds are thus needed. Within this work, application of the bench-stable cyclic hypervalent i

Radical Cyclization of Olefinic Amides through α-C(sp 3)-H Functionalization of Ketones under Catalyst-, Ligand-, and Base-Free Conditions

A new, efficient, and practical radical cyclization of olefinic amides with ketones through α-C(sp 3)-H functionalization in the presence of tert -butyl peroxybenzoate (TBPB) is described for the first time. This protocol assembles a wide range of pivotal and useful benzoxazines in good to excellent yields under mild, catalyst-free, ligand-free, and base-free conditions with wide functional group tolerance. Moreover, the mechanistic study indicates that the α-carbonyl radical is involved in this transformation.

Mapping Dual-Base-Enabled Nickel-Catalyzed Aryl Amidations: Application in the Synthesis of 4-Quinolones

The C?N cross-coupling of (hetero)aryl (pseudo)halides with NH substrates employing nickel catalysts and organic amine bases represents an emergent strategy for the sustainable synthesis of (hetero)anilines. However, unlike protocols that rely on photoredox/electrochemical/reductant methods within NiI/III cycles, the reaction steps that comprise a putative Ni0/II C?N cross-coupling cycle for a thermally promoted catalyst system using organic amine base have not been elucidated. Here we disclose an efficient new nickel-catalyzed protocol for the C?N cross-coupling of amides and 2′-(pseudo)halide-substituted acetophenones, for the first time where the (pseudo)halide is chloride or sulfonate, which makes use of the commercial bisphosphine ligand PAd2-DalPhos (L4) in combination with an organic amine base/halide scavenger, leading to 4-quinolones. Room-temperature stoichiometric experiments involving isolated Ni0, I, and II species support a Ni0/II pathway, where the combined action of DBU/NaTFA allows for room-temperature amide cross-couplings.

Oxidative Cleavage of Indoles Mediated by Urea Hydrogen Peroxide or H2O2 in Polar Solvents

The oxidative cleavage of indoles (Witkop oxidation) involving the use of H2O2 or urea hydrogen peroxide in combination with a polar solvent has been described. Among these solvents, 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) stands out as the one affording the corresponding 2-ketoacetanilides generally in higher yields The protocol described has also enabled the oxidation of different pyrroles and furans derivatives. Furthermore, the procedure was implemented in a larger-scale and HFIP was distilled from the reaction mixture and reused (up to 4 cycles) without a significant detriment in the reaction outcome, which remarks its sustainability and applicability. (Figure presented.).

Synthesis and biological evaluation of 2-phenyl-4-aminoquinolines as potential antifungal agents

Abstract: A series of 2-phenyl-4-aminoquinolines were designed, synthesized and evaluated for their antifungal activities against three phytopathogenic fungi in vitro. All of the target compounds were fully elucidated by 1H NMR, 13C

Rational modification, synthesis and biological evaluation of 3,4-dihydroquinoxalin-2(1H)-one derivatives as potent and selective c-Jun N-terminal kinase 3 (JNK3) inhibitors

The c-Jun N-terminal kinase 3 (JNK3) plays key roles in a wide range of diseases, including neurodegeneration diseases, inflammation diseases, cancers, cardiovascular diseases, and metabolic disorders. Previously, we have identified a lead compound, (Z)-3

Synthesis, in vitro and in vivo biological evaluation of novel graveolinine derivatives as potential anti-Alzheimer agents

A novel series of graveolinine derivatives were synthesized and evaluated as potential anti-Alzheimer agents. Compound 5f exhibited the best inhibitory activity for acetylcholinesterase (AChE) and had surprisingly potent inhibitory activity for butyrylcho

Cp*Co(III)-catalyzed C[sbnd]H amidation of azines with dioxazolones

Cp*Co(III)-catalyzed direct C[sbnd]H amidation of azines has been developed. This conversion could proceed smoothly in the absence of external oxidants, acids or bases, with excellent regioselectivity and broad functional group tolerance. CO2 w

Method for preparing derivatives of benzamide under microwave condition in aqueous phase

The invention discloses a method for preparing derivatives of benzamide under a microwave condition in an aqueous phase. A coupling reaction is carried out between substituted benzoic acid and amine under the microwave condition in the aqueous phase. The method for preparing the derivatives of benzamide is environmentally friendly, easy and convenient to operate, safe, low in cost and efficient. Compared with the prior art, the method can be applicable to a large number of functional groups, is high in yield, produces fewer by-products, and further is easy to operate, safe, low in cost and environmentally friendly. A formula is shown in the description.

Method for synthesizing amide compound through photocatalysis in water phase

The invention discloses a method for synthesizing an amide compound through photocatalysis in a water phase. The method comprises the following steps: putting catalysis amounts of a free radical initiator, an amine derivative, a carboxylic acid derivative, a phase transfer catalyst, an inorganic base and water into a reaction container, carrying out a reaction in a photocatalysis reaction instrument at certain power under a room temperature condition, after a certain time, carrying out extraction by using a small amount of ethyl acetate, and carrying out recrystallization, so as to obtain theamide compound, wherein the free radical initiator is eosin, methyl orange, sodium persulfate, ammonium persulfate or potassium peroxodisulfate, the phase transfer catalyst is tetrabutylammonium bromide, and the power of the photocatalytic reaction instrument is 5W. By adopting the method disclosed by the invention, toxic thionyl chloride or phosphorus oxychloride is not needed for a chlorinationreaction, water is adopted as a solvent, a novel photocatalysis method is used, and the amide compound with a high yield can be prepared through a room-temperature reaction for 2-5 hours with an incandescent light bulb of 5W, and in addition, the method is simple in aftertreatment, and low in cost and is an ideal green synthesis method of amide compounds.