314054-36-9 Usage
Uses
Used in Neuroprotection:
HIOC is used as a neuroprotective agent for the treatment of early brain injury following subarachnoid hemorrhage (SAH). It helps in reducing the damage caused to the brain by modulating the TrkB receptor, which plays a crucial role in neuronal survival and synaptic plasticity.
Used in Ophthalmology:
In the field of ophthalmology, HIOC is used as a protective agent to safeguard retinas from retinal degradation. Its agonistic action on the TrkB receptor helps in maintaining the health and function of retinal cells, potentially preventing vision loss and other retinal disorders.
Used in Pharmaceutical Research:
HIOC's unique properties as a selective TrkB receptor agonist make it a valuable compound for pharmaceutical research. It can be further studied and developed into new therapeutic agents for various neurological and ophthalmological conditions, as well as for potential applications in other areas of medicine.
Used in Drug Delivery Systems:
Similar to gallotannin, HIOC can also be incorporated into novel drug delivery systems to enhance its applications and efficacy. These systems can be designed to improve the delivery, bioavailability, and therapeutic outcomes of HIOC, making it a more effective treatment option for the conditions it targets.
Check Digit Verification of cas no
The CAS Registry Mumber 314054-36-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,1,4,0,5 and 4 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 314054-36:
(8*3)+(7*1)+(6*4)+(5*0)+(4*5)+(3*4)+(2*3)+(1*6)=99
99 % 10 = 9
So 314054-36-9 is a valid CAS Registry Number.
314054-36-9Relevant academic research and scientific papers
Setterholm, Noah A.,McDonald, Frank E.,Boatright, Jeffrey H.,Iuvone, P. Michael
, p. 3413 - 3415 (2015)
N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-2-oxopiperidine-3-carboxamide (HIOC) is a potent activator of the TrkB receptor in mammalian neurons and of interest because of its potential therapeutic uses. In the absence of a commercial supply of HIOC, we sought to produce several grams of material. However, a synthesis of HIOC has never been published. Herein we report the preparation of HIOC by the chemoselective N-acylation of serotonin, without using blocking groups in the key acylation step.
