31437-05-5

Basic information

• Product Name: N-Pyrazinylthiourea
• Synonyms: N-Pyrazinylthiourea;1-(Pyrazin-2-Yl)Thiourea;-Pyrazinylthiourea
• CAS NO: 31437-05-5
• Molecular Formula: C₅H₆N₄S
• Molecular Weight: 154.19
• Mol File: 31437-05-5.mol
• Article Data: 12

Chemical Properties

• Melting Point: 128 °C
• Boiling Point: 311.6°Cat760mmHg
• Flash Point: 142.3°C
• Appearance: /
• Density: 1.482g/cm³
• Vapor Pressure: 0.000557mmHg at 25°C
• Refractive Index: 1.761
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 11.25±0.70(Predicted)
• CAS DataBase Reference: N-Pyrazinylthiourea(CAS DataBase Reference)
• NIST Chemistry Reference: N-Pyrazinylthiourea(31437-05-5)
• EPA Substance Registry System: N-Pyrazinylthiourea(31437-05-5)

Safety Data

• Hazardous Substances Data: 31437-05-5(Hazardous Substances Data)

Usage

General Description

N-Pyrazinylthiourea is a chemical compound with the molecular formula C5H7N3S. It is a member of the thiourea class of compounds, which are known for their wide range of biological and industrial applications. N-Pyrazinylthiourea has been studied for its potential as a pesticide, herbicide, and fungicide due to its ability to inhibit enzymes involved in plant metabolism. Additionally, it has been investigated for its antimicrobial properties and potential use in pharmaceuticals. N-Pyrazinylthiourea is also a building block for the synthesis of pharmaceutical compounds. Despite its numerous potential applications, further research is needed to fully understand its properties and potential uses.

InChI:InChI=1/C5H6N4S/c6-5(10)9-4-3-7-1-2-8-4/h1-3H,(H3,6,8,9,10)

Upstream product

• 5049-61-6 2-Aminopyrazine 
• 333-20-0 potassium thioacyanate 
• 71306-89-3 1-phenyl-3-pyrazin-2-yl-thiourea 
• 1310-73-2 sodium hydroxide 
• 532-55-8 Benzoyl isothiocyanate 
• 31437-04-4 1-benzoyl-3-pyrazin-2-yl-thiourea 
• 56406-73-6 ethyl[(pyrazin-2-ylamino)carbonothioyl]carbamate 

Downstream Products

• 915702-00-0 2-bromo-1-[4-methyl-2-(pyrazin-2-ylamino)-1,3-thiazol-5-yl]ethanone hydrobromide 
• 1266676-68-9 [4-(3,4-dimethoxyphenyl)-thiazol-2-yl]-pyrazin-2-yl-amine 
• 431040-27-6 3-[5-Bromo-2-(pyrazin-2-ylamino)-thiazol-4-yl]-benzonitrile 
• 156272-82-1 N-(pyrazin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine 

Relevant articles and documents

The synthesis of 2-amino-4(3H)-quinazolinones and related heterocycles via a mild electrocyclization of aryl guanidines

A new method for the preparation of 2-amino-4(3H)-quinazolinones and similar fused heterocycles is described. Simply warming a mixture of an aryl guanidine and carbonyl diimidazole in acetonitrile results in formation of a putative N-amidinoisocyanate intermediate which undergoes a 6π-electron electrocyclic reaction with the aryl ring to generate the quinazolinone ring system. The mild conditions are compatible with a variety of functional groups, and the reaction is shown to be successful on multigram scale.

SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF CANCERS, INCLUDING HEPATOCELLULAR CARCINOMA, AND AS INHIBITORS OF HEPATITIS VIRUS REPLICATION

Pharmaceutical compositions of the invention are presented which comprise substiuted aminothiazoles derivatives. The substiuted aminothiazoles derivatives have a disease-modifying action in the treatment of diseases associated with unregulated cell growth. Such diseases include cancers such as hepatocellular carcinoma, and viral infections from a hepatitis virus.

THIAZOLE DERIVATIVES AND USE THEREOF

The present invention is related to thiazole derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.