3144-04-5

Usage

Uses

Used in Pharmaceutical Industry:
Butane-1-sulfonamide is used as an intermediate in the synthesis of various pharmaceuticals. Its unique chemical structure allows it to be incorporated into the development of new drugs, contributing to the advancement of medicine.
Used in Agrochemical Industry:
In the agrochemical sector, butane-1-sulfonamide is utilized as a precursor in the production of herbicides and insecticides. Its properties make it suitable for creating effective and targeted agricultural chemicals.
Used in Specialty Chemicals Production:
Butane-1-sulfonamide is employed as a building block in the synthesis of specialty chemicals. Its versatility in organic synthesis allows it to be used in the creation of a wide range of specialty products.
Used as a Corrosion Inhibitor:
Butane-1-sulfonamide serves as a corrosion inhibitor for metal surfaces. Its application helps protect metals from degradation, extending their lifespan and improving their performance in various industrial settings.
Used in Polymer Synthesis:
In the field of polymer chemistry, butane-1-sulfonamide is used as a component in the synthesis of certain polymers. Its incorporation into polymer structures can enhance their properties and contribute to the development of new materials with specific characteristics.

Upstream product

• 2386-60-9 perfluoro-1-butanesulfonyl fluoride 
• 109-72-8 n-butyllithium 
• 3670-24-4 n-butylsulphonyl isocyanate 
• 109-65-9 1-bromo-butane 

Downstream Products

• 63884-88-8 (butane-1-sulfonyl)-carbamic acid pentyl ester 
• 5454-59-1 N-(phenylcarbamoyl)butane-1-sulfonamide 
• 105143-03-1 N-(butane-1-sulfonyl)-N'-p-tolyl-thiourea 
• 99988-10-0 N-(butane-1-sulfonyl)-N'-(4-nitro-phenyl)-urea 
• 5454-60-4 N-(butane-1-sulfonyl)-N'-p-tolyl-urea 
• 99857-78-0 N-(butane-1-sulfonyl)-N'-(4-chloro-phenyl)-thiourea 
• 101582-53-0 α--diphenylmethan 
• 104448-67-1 2-Ethyl-hexanoic acid {1-[4-(butane-1-sulfonylaminocarbonyl)-2-methoxy-benzyl]-1H-indol-6-yl}-amide 

Relevant academic research and scientific papers

Nickel complexes with phosphines and N-R-sulfonyldithiocarbimates ligands: New antifungals for the control of Hemileia vastatrix and Phakopsora pachyrhizi

Nickel(II) complexes of general formula [Ni(RSO2N = CS2)(PPh3)2] (2a–h) or [Ni(RSO2N = CS2)dppe] (3a–h), where R = methyl (a), ethyl (b), butyl (c), octyl (d), phenyl (e), 4-isopropylphenyl (f), 4-tert-butylphenyl (g), 2-naphthyl (h), PPh3 = triphenylphosphine and dppe = 1,2-bis(diphenylphosphine)ethane were prepared, from which six are new substances (2f–h and 3f–h). The new compounds were characterized by elemental analysis of C, H, N and Ni, and by IR, UV–Vis and 1H, 13C and 31P NMR spectroscopies. The data were consistent with the formation of square planar nickel(II) complexes with mixed ligands, what was confirmed by single crystal X-ray diffraction studies on compounds 2f and 2h. These complexes present intramolecular Ni–H–C anagostic interactions. All complexes inhibited the germination of Hemileia vastatrix and Phakopsora pachyrhizi, the causal agents of devastating diseases on soybean and coffee cultures. The most active compounds presented IC90 values as low as 405 μM against H. vastatrix, and 280 μM against P. pachyrhizi. Thus, the title compounds are target molecules for the development of new agrochemicals against the Asian soybean rust and Coffee leaf-rust diseases.

Synthesis of Sultams and Cyclic N-Sulfonyl Ketimines via Iron-Catalyzed Intramolecular Aliphatic C-H Amidation

Cyclic sulfonamides (sultams) play a unique role in drug discovery and synthetic chemistry. A direct synthesis of sultams by an intramolecular C(sp3)-H amidation reaction using an iron complex in situ derived from Fe(ClO4)2 and aminopyridine ligand is reported. This strategy features a readily available catalyst and tolerates a broad variety of substrates as demonstrated by 22 examples (up to 89% yield). A one-pot iron-catalyzed amidation/oxidation procedure for the synthesis of cyclic N-sulfonyl ketimines is also realized with up to 92% yield (eight examples). The synthetic utility of the method is validated by a gram-scale reaction and derivatization of the products to ring-fused sultams.

THIAZOLIDINONE COMPOUNDS AND USE THEREOF

A pharmaceutical composition containing a compound of Formula (I) for treating an opioid receptor-associated condition. Also disclosed is a method for treating an opioid receptor-associated condition using such a compound. Further disclosed are two sets of thiazolidinone compounds of formula (I): (i) compounds each having an enantiomeric excess greater than 90% and (ii) compounds each being substituted with deuterium.

Cu-catalyzed aerobic oxidative three-component coupling route to N -sulfonyl amidines via an ynamine intermediate

Cu-catalyzed aerobic oxidative three-component coupling of a terminal alkyne, secondary amine, and sulfonamide enables efficient synthesis of amidines. The use of Cu(OTf)2 (5 mol %) produces amidines selectively without Glaser-Hay alkyne homocoupling products. Preliminary studies suggest that the reaction pathway involves initial oxidative coupling of the terminal alkyne with the secondary amine, followed by hydroamidation of the ynamine intermediate with the sulfonamide.

Synthesis, characterization, and antifungal activity of novel (Z)-N-(2-cyano-3-phenylprop-2-en-1-yl)-alkyl/aryl-sulfonamides derived from a Morita-Baylis-Hillman adduct

A series of allyl sulfonamides prepared from the reaction of the Morita-Baylis-Hillman adduct 2-[hydroxy(phenyl)methyl]acrylonitrile with primary sulfonamides (RSO2NH2), where R = C6H 5 (1), 4-FC6H4 (2), 4-ClC6H 4 (3), 4-BrC6H4 (4), 4-NO2C 6H4 (5), CH3 (6), CH3CH2 (7), CH3(CH2)3 (8), and CH3(CH 2)7 (9), were characterized by IR, 1H and 13C NMR spectroscopies, mass spectrometry and elemental analyses. BLYP/6-31G* calculations suggested stereoselective reactions, resulting in the exclusive formation of the thermodynamically more stable Z-products. The Z-configuration of the products was confirmed by NOE difference spectroscopy and single crystal X-ray diffraction measurements. The allyl sulfonamides were active against Colletotrichum gloeosporioides, an important agent of anthracnose in plants.

Synthesis and investigation of inhibition effect of fluorinated sulfonamide derivatives on carbonic anhydrase

Series of perfluoroalkanesulfonamides 1, sodium salt of perfluoroalkanesulfonamides 2 and polyfluoroalkanesulfonamides 3 derivatives were synthesized and characterized by 1H NMR, 13C NMR, 19F NMR, IR and HRMS. Inhibition effects of these compounds on bovine carbonic anhydrase (bCA) and human carbonic anhydrase isoenzyme II (hCA) have been investigated. Comparing IC50 values of the synthesized molecules 1, 2 and 3, it has been found that compound 2b is a more potent inhibitor than acetazolamide on hCA. Moreover 2b does not present cellular toxicity on sheep red globules.

Syntheses, crystal structure and spectroscopic characterization of bis(dithiocarbimato)-nickel(II)-complexes: A new class of vulcanization accelerators

The compounds (Ph4P)2[Ni(RSO2NCS 2)2] [Ph4P+= tetraphenylphosphonium cation; R = CH3 (1b), CH3CH2 (2b), CH 3(CH2)3/su

Analogs of isovaleramide, a pharmaceutical composition including the same, and a method of treating central nervous system conditions or diseases

An isovaleramide analog having at least one of an increased potency, an increased half-life, and an increased stability compared to isovaleramide. The isovaleramide analog is a cyclic analog or a noncyclic analog. The isovaleramide analog is formulated into a pharmaceutical composition. A method of treating a central nervous system condition or disease is also disclosed. The method comprises administering an isovaleramide analog to a patient suffering from the central nervous system condition or disease.

Intramolecular asymmetric amidations of sulfonamides and sulfamates catalyzed by chiral dirhodium(II) complexes

Enantioselective intramolecular amidation of aliphatic sulfonamides was achieved for the first time by means of chiral carboxylatodirhodium(II) catalysts in conjunction with PhI(OAc)2 and MgO in high yields and with enantioselectivities of up to 66% (Scheme 3, Table 1). The best results were obtained with [Rh2{(S)-nttI)4] and [Rh 2{(R)-ntv)4] as catalysts ((S)-nttl = (αS)-α- (tert-butyl)-1,3-dioxo-2H-benz[de]isoquinoline-2-acetato, (R)-nto = (αR)-α-isopropyl-1,3-dioxo-2H-benz[de] isoquinoline-2-acetato). In addition, these carboxylatodirhodium(II) catalysts were also efficient in intramolecular amidations of aliphatic sulfamates esters, although the enantioselectivity of these latter reactions was significantly lower (Scheme 4, Table 3).

Pyridyl-containing spirocyclic compounds as inhibitors of fibrinogen-dependent platelet aggregation

Disclosed are certain substituted or unsubstituted pyridyl-containing spirocyclic compounds substituted with both basic and acidic functionality, which are useful in inhibiting platelet aggregation, inhibiting the binding of fibrinogen to blood platelets, and preventing or treating thrombosis