314745-06-7

Basic information

• Product Name: methyl 2-((5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)acetate
• Synonyms: methyl 2-((5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)acetate
• CAS NO: 314745-06-7
• Molecular Weight: 326.306
• Mol File: 314745-06-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: methyl 2-((5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-((5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)acetate(314745-06-7)
• EPA Substance Registry System: methyl 2-((5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)acetate(314745-06-7)

Safety Data

• Hazardous Substances Data: 314745-06-7(Hazardous Substances Data)

Upstream product

• 480-40-0 5,7-dihydroxy-2-phenyl-chromen-4-one 
• 96-32-2 bromoacetic acid methyl ester 

Downstream Products

• 1447463-70-8 N-(4-bromopyridin-2-yl)-2-((5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)acetamide 
• 920430-49-5 2-((5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)-N-(pyridin-2-yl)acetamide 
• 1447463-72-0 N-(3-fluoropyridin-2-yl)-2-((5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)acetamide 
• 1447463-73-1 2-((5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)-N-(m-tolyl)acetamide 
• 892563-31-4 2-((5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)-N-(p-tolyl)acetamide 
• 859141-05-2 N-(4-bromophenyl)-2-((5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)acetamide 
• 1447463-74-2 N-(3-bromophenyl)-2-((5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)acetamide 
• 1447463-75-3 N-(2-bromophenyl)-2-((5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)acetamide 
• 1447463-76-4 2-((5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)-N-(3-methoxyphenyl)acetamide 
• 1447463-77-5 N-benzyl-2-((5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)acetamide 
• 1447463-78-6 2-((5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)-N-(2-morpholinoethyl)acetamide 
• 97980-71-7 2-((5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)acetic acid 
• 929844-15-5 C₂₃H₁₈N₂O₅ 
• 1447463-68-4 2-((5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)-N-(5-methylpyridin-2-yl)acetamide 

Relevant articles and documents

Novel Chrysin-de-allyl PAC-1 hybrid analogues as anticancer compounds: Design, synthesis, and biological evaluation

New chrysin-De-allyl-Pac-1 hybrid analogues, tethered with variable heterocyclic systems (4a-4o), were rationally designed and synthesized. The target compounds were screened for in vitro antiproliferative efficacy in the triple-negative breast cancer (TNBC) cell line, MDA-MB-231, and normal human mammary epithelial cells (HMECs). Two compounds, 4g and 4i, had the highest efficacy and selectivity towards MDA-MB-231 cells, and thus, were further evaluated by mechanistic experiments. The results indicated that both compounds 4g and 4i induced apoptosis by (1) inducing cell cycle arrest at the G2 phase in MDA-MB-231 cells, and (2) activating the intrinsic apoptotic pathways in a concentration-dependent manner. Physicochemical characterizations of these compounds suggested that they can be further optimized as potential anticancer compounds for TNBC cells. Overall, our results suggest that 4g and 4i could be suitable leads for developing novel compounds to treat TNBC.

NO donor compounds, compositions, preparation method and application thereof

The object of the present invention is to provide NO donor compounds, compositions, a preparation method and application thereof. The compounds and the compositions show high anticancer activity in in-vitro anticancer activity tests, and have inhibitory a