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Ethyl 2-[(4-methoxyphenyl)amino]-4-oxo-4,5-dihydrofuran-3-carboxylate is a complex organic compound with the molecular formula C14H15NO5. It is a derivative of furan, a heterocyclic compound with a five-membered ring containing four carbon atoms and one oxygen atom. The molecule features a 4-methoxyphenyl group attached to the furan ring through an amino group, and a carboxylate group at the 3-position. ethyl 2-[(4-methoxyphenyl)amino]-4-oxo-4,5-dihydrofuran-3-carboxylate is known for its potential applications in the synthesis of various pharmaceuticals and agrochemicals, particularly as an intermediate in the production of certain drugs. Its chemical structure and properties make it a versatile building block in organic synthesis, allowing for the creation of a wide range of molecules with different biological activities.

3148-33-2

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3148-33-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 3148-33-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,1,4 and 8 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 3148-33:
(6*3)+(5*1)+(4*4)+(3*8)+(2*3)+(1*3)=72
72 % 10 = 2
So 3148-33-2 is a valid CAS Registry Number.

3148-33-2Relevant academic research and scientific papers

Discovery of novel furanone derivatives as potent Cdc7 kinase inhibitors

Irie, Takayuki,Asami, Tokiko,Sawa, Ayako,Uno, Yuko,Hanada, Mitsuharu,Taniyama, Chika,Funakoshi, Yoko,Masai, Hisao,Sawa, Masaaki

, p. 406 - 418 (2017/03/11)

Cdc7 is a serine-threonine kinase and plays a conserved and important role in DNA replication, and it has been recognized as a potential anticancer target. Herein, we report the design, synthesis and structure-activity relationship of novel furanone derivatives as Cdc7 kinase inhibitors. Compound 13 was identified as a strong inhibitor of Cdc7 with an IC50 value of 0.6?nM in the presence of 1?mM ATP and showed excellent kinase selectivity. In addition, it exhibited slow off-rate characteristics, which may offer advantages over known Cdc7 inhibitors in its potential to yield prolonged inhibitory effects in?vivo. Compound 13 potently inhibited Cdc7 activity in cancer cells, and effectively induced cell death.

NOVEL FURANONE DERIVATIVE

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Paragraph 0068; 0069; 0070, (2014/02/16)

To provide a novel furanone derivative, and a medicine including the same. The furanone derivative is represented by the formula (I): wherein A represents —COOR1 or a hydrogen atom; R1 represents a hydrogen atom, an optionally substituted hydrocarbon grou

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