31519-52-5

Usage

Uses

Used in Pharmaceutical Industry:
(R)-1,2-dimethylpropylamine hydrochloride is used as a pharmaceutical intermediate for the synthesis of various drugs. Its role in drug development is crucial, as it serves as a building block for creating a range of medicinal compounds with different therapeutic properties.
Used in Organic Synthesis:
In the field of organic chemistry, (R)-1,2-dimethylpropylamine hydrochloride is utilized as a reagent. Its amine functional group allows for a variety of chemical reactions, making it a valuable component in the synthesis of complex organic molecules.
Used in Corrosion Inhibition:
(R)-1,2-dimethylpropylamine hydrochloride is also employed as a corrosion inhibitor in various industries. Its ability to prevent or reduce the rate of corrosion on metal surfaces makes it an important compound in industrial applications, where the protection of metal structures from degradation is essential.

Upstream product

• 51859-00-8 (R)-N-1-(i-propyl)ethyltosylamide 
• 293305-73-4 tert-butyl (1R)-1,2-dimethylpropyl carbamate 
• 2026-48-4 (S)-valinol 
• 563-80-4 3-methyl-butan-2-one 
• 866993-51-3 (R)-N-(3-methylbutan-2-ylidene)-2-methylpropane-2-sulfinamide 
• 55424-48-1 (S)-2-(4-methylphenylsulfonylamino)-1-(4-methylsulfonyloxy)-3-methylbutane 
• 4070-48-8 L-Valine methyl ester 
• 72-18-4 L-valine 
• 161529-21-1 (S)-(1-iodomethyl-2-methylpropyl)carbamic acid tert-butyl ester 
• 79069-14-0 (S)-2-<(tert-butoxycarbonyl)amino>-3-methylbutan-1-ol 

Downstream Products

• 1012310-39-2 (R)-N-benzoyl-3-methyl-2-butylamine 
• 677742-12-0 C₁₆H₁₇Cl₂N₃O₂ 
• 101689-08-1 (R)-N-((R)-1,2-Dimethyl-propyl)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionamide 
• 31458-27-2 N-((R)-1,2-Dimethyl-propyl)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionamide 

Relevant academic research and scientific papers

A one-pot asymmetric sequential animation-alkylation of aldehydes: Expedient synthesis of aliphatic chiral amines

A one-pot asymmetric sequential amination-alkylation method has been developed for the synthesis of alkyl-alkyl′ α-chiral primary amines (aliphatic primary amines with a chiral center adjacent to the nitrogen atom) from aldehydes. In situ aldimine formati

Enantiospecific C-H Activation Using Ruthenium Nanocatalysts

The activation of C-H bonds has revolutionized modern synthetic chemistry. However, no general strategy for enantiospecific C-H activation has been developed to date. We herein report an enantiospecific C-H activation reaction followed by deuterium incorporation at stereogenic centers. Mechanistic studies suggest that the selectivity for the α-position of the directing heteroatom results from a four-membered dimetallacycle as the key intermediate. This work paves the way to novel molecular chemistry on nanoparticles.

Microwave-Enhanced Asymmetric Transfer Hydrogenation of N-(tert-Butylsulfinyl)imines

Microwave irradiation has considerably enhanced the efficiency of the asymmetric transfer hydrogenation of N-(tert-butylsulfinyl)imines in isopropyl alcohol catalyzed by a ruthenium complex bearing the achiral ligand 2-amino-2-methylpropan-1-ol. In addition to shortening reaction times for the transfer hydrogenation processes to only 30 min, the amounts of ruthenium catalyst and isopropyl alcohol can be considerably reduced in comparison with our previous procedure assisted by conventional heating, which diminishes the environmental impact of this new protocol. This methodology can be applied to aromatic, heteroaromatic and aliphatic N-(tert-butylsulfinyl)ketimines, leading, after desulfinylation, to the expected primary amines in excellent yields and with enantiomeric excesses of up to 96 %. Microwave irradiation promotes the asymmetric transfer hydrogenation of N-(tert-butylsulfinyl)imines in 2-propanol catalysed by a ruthenium complex bearing an achiral β-amino alcohol as ligand. After desulfinylation, α-branched primary amines containing aromatic, heteroaromatic and aliphatic substituents are obtained in excellent yields and with enantiomeric excesses of up to 96 %.

A versatile Ru catalyst for the asymmetric transfer hydrogenation of both aromatic and aliphatic sulfinylimines

A highly efficient Ru catalyst based on an achiral, very simple, and inexpensive amino alcohol ligand (2-amino-2-methylpropan-1-ol) has been developed for the asymmetric transfer hydrogenation (ATH) of chiral N-(tert-butylsulfinyl)imines. This complex is able to catalyze the ATH of both aromatic and the most challenging aliphatic sulfinylimines by using isopropyl alcohol as the hydrogen source. The diastereoselective reduction of aromatic, heteroaromatic, and aliphatic sulfinylketimines, including sterically congested cases, over short reaction times (1-4 h), followed by desulfinylation of the nitrogen atom, affords the corresponding highly enantiomerically enriched (ee up to >99%) α-branched primary amines in excellent yields. The same ligand was equally effective for the synthesis of both (R)- and (S)-amines by using the appropriate absolute configuration in the iminic substrate. DFT mechanistic studies show that the hydrogen-transfer process is stepwise. Moreover, the origin of the diastereoselectivity has been rationalized.

SULPHONAMIDOANILINE DERIVATIVES BEING JANUS KINASES INHIBITORS

The invention relates to sulphonamidoanilines of formula (I) wherein A is N or CH, W, X, Y and Z are N or CH under the proviso that at least one of the three symbols W, X and Y represent CH, R1 represents NR4R5 or OR4

SYNTHESIS OF THE RACEMIC FORM OF (Z)-1,17-DIAMINOOCTADEC-9-ENE, AN ALIPHATIC DIAMINE FROM COCCINELLIDAE. DETERMINATION OF THE ABSOLUTE CONFIGURATION OF THE (+)-NATURALLY-OCCURRING ANTIPODE

The total synthesis of the title compound (1) has been achieved.Also reported is the use of lanthanide induced shifts in 1H NMR spectroscopy to assign the absolute configuration of the α-carbon atom in chiral primary α-methylalkylamines.Application of this empirical method to natural (+)-1 shows that it has the R-configuration at C-17.