315194-71-9

Basic information

• Product Name: Benzamide, N-[1,1'-biphenyl]-4-yl-2-chloro-5-nitro-
• CAS NO: 315194-71-9
• Molecular Formula: C19H13ClN2O3
• Molecular Weight: 352.777
• Mol File: 315194-71-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzamide, N-[1,1'-biphenyl]-4-yl-2-chloro-5-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-[1,1'-biphenyl]-4-yl-2-chloro-5-nitro-(315194-71-9)
• EPA Substance Registry System: Benzamide, N-[1,1'-biphenyl]-4-yl-2-chloro-5-nitro-(315194-71-9)

Safety Data

• Hazardous Substances Data: 315194-71-9(Hazardous Substances Data)

Upstream product

• 25784-91-2 2-chloro-5-nitrobenzoylchloride 
• 2113-61-3 biphenyl-4-ylamine; hydrochloride 
• 144-55-8 sodium hydrogencarbonate 
• 92-67-1 4-phenylalanine 

Relevant articles and documents

Optimization of chloronitrobenzamides (CNBs) as therapeutic leads for human African trypanosomiasis (HAT)

We previously reported the discovery of the activity of chloronitrobenzamides (CNBs) against bloodstream forms of Trypanosoma brucei. Herein we disclose extensive structure-activity relationship and structure-property relationship studies aimed at identification of tractable early leads for clinical development. These studies revealed a promising lead compound, 17b, that exhibited nanomolar potency against T. brucei (EC 50 = 27 nM for T. b. brucei, 7 nM for T. b. rhodesiense, and 2 nM for T. b. gambiense) with excellent selectivity for parasite cells relative to mammalian cell lines (EC50 > 25 μM). In addition compound 17b displayed suitable physiochemical characteristics and microsomal stability (t1/2 > 4 h for human and mouse) to justify pursuing in vivo studies.