31545-27-4

Basic information

• Product Name: Methanone, (4-chloro-3-nitrophenyl)(4-methoxyphenyl)-
• CAS NO: 31545-27-4
• Molecular Formula: C14H10ClNO4
• Molecular Weight: 291.691
• Mol File: 31545-27-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Methanone, (4-chloro-3-nitrophenyl)(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, (4-chloro-3-nitrophenyl)(4-methoxyphenyl)-(31545-27-4)
• EPA Substance Registry System: Methanone, (4-chloro-3-nitrophenyl)(4-methoxyphenyl)-(31545-27-4)

Safety Data

• Hazardous Substances Data: 31545-27-4(Hazardous Substances Data)

Upstream product

• 100-66-3 methoxybenzene 
• 38818-50-7 4-chloro-3-nitro-benzoyl chloride 
• 10547-60-1 4-chloro-4'-methoxybenzophenone 

Downstream Products

• 215959-24-3 2-[4-(4-Methoxy-benzoyl)-2-nitro-phenyl]-malonic acid diethyl ester 
• 1159693-47-6 C₁₄H₁₂ClNO₂ 
• 93958-49-7 ethyl 5(6)-<4-hydroxy-3-(4-methylpiperazin-1-ylmethyl)benzoyl>benzimidazole-2-carbamate 
• 93958-53-3 4'-hydroxy-4-(4-methylpiperazin-1-yl)-3-nitrobenzophenone 
• 93958-46-4 3,4-diamino-4'-hydroxy-3'-(4-methylpiperazin-1-yl)methylbenzophenone 
• 93958-41-9 4-chloro-4'-hydroxy-3'-(4-methylpiperazin-1-yl)methyl-3-nitrobenzophenone 
• 93958-43-1 4-amino-4'-hydroxy-3'-(4-methylpiperazin-1-yl)methyl-3-nitrobenzophenone 
• 93958-48-6 ethyl 5⁽⁶⁾-(4-hydroxybenzoyl)benzimidazole-2-carbamate 
• 93958-54-4 3-amino-4'-hydroxy-4-(4-methylpiperazin-1-yl)benzophenone 
• 93958-52-2 5⁽⁶⁾-(4-hydroxybenzoyl)-2-trifluoromethyl-benzimidazol 
• 60014-09-7 4-amino-4'-hydroxy-3-nitrobenzophenone 
• 94495-10-0 5⁽⁶⁾-(4-hydroxybenzoyl)-2-methyl-benzimidazol 
• 93958-50-0 5⁽⁶⁾-(4-hydroxybenzoyl)benzimidazol-2-one 
• 93958-51-1 5⁽⁶⁾-(4-hydroxybenzoyl)benzimidazol 

Relevant articles and documents

Synthesis and antioxidant potential of novel synthetic benzophenone analogues

Considering that oxidative stress is strongly implicated in the toxicity of chemotherapy, much effort is focused on the research of diverse antioxidants as protective agents. An efficient synthesis of three novel benzophenones containing 1,3-thiazol moiety (6a-c) is described. Their antioxidant power was evaluated in vitro and in three cell lines (the cancerous MCF7 and the non-cancerous hTERT-HME1 mammary cells, and the H9c2 cardiomyoblastic cells). One analogue 5-(2,5-dihydroxybenzoyl)-2(3H)-benzothiazolone (6c), displayed an important antioxidant activity, a low cytotoxicity, and could decrease reactive oxygen species production generated by tert-butyl hydroperoxide (tBHP) in all three cell lines. Interestingly, 6c was able to protect the non-cancerous cells against tBHP-induced death. Further studies are underway to determine its relevance as an adjuvant in oxidative stress inducing chemotherapy.

Synthesis and anthelminthic acitivity of alkyl-(5-acyl-1-benzimidazol-2-yl) carbamates

A series of alkyl-(5-acyl-l-H-benzimidazol-2-yl)-carbamates were prepared and screened for anthelminthic activity. Some of them were found to be fully active at low, atoxic oral dose levels against gastro-intestinal nematodes. The activity against Syphacia muris and Strongyloides ratta is indicated. From these studies methyl (5-benzoyl-1-H-benzimidazol-2-yl) carbamate (mebendazole) and methyl [5-(4-fluorobenzoyl)-1-H-benzimidazol-2-yl]carbamate (flubendazole) were selected for detailed investigation.