31558-03-9

Upstream product

• 616-45-5 2-pyrrolidinon 
• 4187-87-5 1-Phenyl-2-propyn-1-ol 
• 936-59-4 3-chloropropiophenone 

Downstream Products

• 116460-93-6 1-aza-2-oxo-6-hydroxy-6-phenyl bicyclo (3.3.0) octane 
• 116460-93-6 1-aza-2-oxo-6-hydroxy-6-phenyl bicyclo (3.3.0) octane 
• 98013-04-8 1,3,5-tribenzoylcyclohexane 

Relevant academic research and scientific papers

The mechanism of cyclotrimerisation of phenylvinylketones and the crystal structures of 1-((1R*,2S*,3R*,5S*)- and 1-((1R*,2S*,3R*,5R*)-3,5-dibenzoyl-2-hydroxy-2- phenylcyclohexylmethyl)-pyrrolidin-2-on

The cyclotrimerisation of 1-phenyl-2-propyn-1-ol (1) with pyrrolidin-2-one (2) to the tribenzoylcyclohexanes 4 and 5 produced - with modifications of the reaction conditions - the phenylvinylketone adducts 17 and 18 as intermediates and additionally the c

Trisubstituted Cyclohexanes

C-Tertiary vinylketones or the corresponding masked vinylketone derivatives react with pyrrolidin-2-one in the system sodium hydride/dimethylsulfoxide to substituted cyclohexanes of the 1,3,5- and sometimes additionally of the 1,2,4-type.Only acetophenone Mannich bases bearing a p-hydroxy or a dimethylamino group failed in cyclization. - Key words: Cyclotrimerisation, Vinylketones, Mannich Bases, NMR Spectra