3157-41-3

Basic information

• Product Name: (2S)-2-amino-4-hydroxypentanedioic acid (non-preferred name)
• Synonyms: (2S)-2-Amino-4-hydroxypentanedioic acid (non-preferred name); hydrogen 4-hydroxy-L-glutamate
• CAS NO: 3157-41-3
• Molecular Formula: C₅H₉NO₅
• Molecular Weight: 163.1287
• Mol File: 3157-41-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 458.7°C at 760 mmHg
• Flash Point: 231.2°C
• Density: 1.595g/cm³
• Vapor Pressure: 2.43E-10mmHg at 25°C
• Refractive Index: 1.565
• CAS DataBase Reference: (2S)-2-amino-4-hydroxypentanedioic acid (non-preferred name)(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-2-amino-4-hydroxypentanedioic acid (non-preferred name)(3157-41-3)
• EPA Substance Registry System: (2S)-2-amino-4-hydroxypentanedioic acid (non-preferred name)(3157-41-3)

Safety Data

• Hazardous Substances Data: 3157-41-3(Hazardous Substances Data)

Usage

General Description

(2S)-2-amino-4-hydroxypentanedioic acid, also known as L-threonine, is a natural amino acid found in many proteins and is an important building block for the human body. It is a non-essential amino acid, meaning it can be synthesized within the body and does not need to be obtained through the diet. L-threonine plays a key role in the formation of collagen, elastin, and tooth enamel, and it also helps to maintain proper protein balance in the body. Additionally, L-threonine is involved in the production of neurotransmitters and can act as a precursor for the synthesis of glycine and serine. It is commonly used as a nutritional supplement in animal feed and is also used in the production of pharmaceuticals, food products, and supplements.

Upstream product

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Relevant articles and documents

LARGE-SCALE ENZYMATIC SYNTHESIS OF DIASTEREOISOMERIC γ-HYDROXY L-GLUTAMIC ACIDS.

Transamination of cysteine sulfinic acid and γ-hydroxy α-acetoglutaric acid, catalyzed by immobilised glutamic oxaloacetic aminotransferase provides a convenient route to γ-hydroxy L-glutamic acids synthesis.

New synthetic routes to α-amino acids and γ-oxygenated α-amino acids. Reductive denitration and oxidative transformations of γ-nitro-α-amino acids

Transformation of γ-nitro-α-amino acid derivatives into α-amino acids by reductive denitration, into the γ-oxo-α-amino acids by ozonolysis of the corresponding amino acid ester nitronate derivatives, and into γ-hydroxy-α-amino acid derivatives by subsequent reduction of the oxo functionality, can be achieved in good yields. As the γ-nitro-α-amino acid derivatives are prepared from N,O-protected dehydroalanines derivable from the corresponding alanine, serine and cysteine derivatives by specific routes, the overall procedures provide a means for selective conversion of these simple α-amino acids into more complex ones.