3157-41-3Relevant academic research and scientific papers
LARGE-SCALE ENZYMATIC SYNTHESIS OF DIASTEREOISOMERIC γ-HYDROXY L-GLUTAMIC ACIDS.
Passerat, N.,Bolte, J.
, p. 1277 - 1280 (1987)
Transamination of cysteine sulfinic acid and γ-hydroxy α-acetoglutaric acid, catalyzed by immobilised glutamic oxaloacetic aminotransferase provides a convenient route to γ-hydroxy L-glutamic acids synthesis.
Stereoselective synthesis of γ-hydroxy-α-amino acids through aldolase-transaminase recycling cascades
Guérard-Hélaine, Christine,Heuson, Egon,Ndiaye, Moussa,Gourbeyre, Léa,Lemaire, Marielle,Hélaine, Virgil,Charmantray, Franck,Petit, Jean-Louis,Salanoubat, Marcel,De Berardinis, Véronique,Gefflaut, Thierry
supporting information, p. 5465 - 5468 (2017/07/06)
Efficient bi-enzymatic cascades combining aldolases and α-transaminases were designed for the synthesis of γ-hydroxy-α-amino acids. These recycling cascades provide high stereoselectivity, atom economy, and an equilibrium shift of the transamination. l-syn or anti-4-hydroxyglutamic acid and d-anti-4,5-dihydroxynorvaline were thus prepared in 83-95% yield in one step from simple substrates.
New synthetic routes to α-amino acids and γ-oxygenated α-amino acids. Reductive denitration and oxidative transformations of γ-nitro-α-amino acids
Crossley, Maxwell J.,Fung, Yik M.,Kyriakopoulos, Efstathia,Potter, Jeffrey J.
, p. 1123 - 1130 (2007/10/03)
Transformation of γ-nitro-α-amino acid derivatives into α-amino acids by reductive denitration, into the γ-oxo-α-amino acids by ozonolysis of the corresponding amino acid ester nitronate derivatives, and into γ-hydroxy-α-amino acid derivatives by subsequent reduction of the oxo functionality, can be achieved in good yields. As the γ-nitro-α-amino acid derivatives are prepared from N,O-protected dehydroalanines derivable from the corresponding alanine, serine and cysteine derivatives by specific routes, the overall procedures provide a means for selective conversion of these simple α-amino acids into more complex ones.
