31579-41-6

Upstream product

• 54633-20-4 1-nitro-2-nitroso-cyclopentane 
• 141-97-9 ethyl acetoacetate 
• 544-13-8 Glutaronitrile 
• 64-19-7 acetic acid 
• 3008-40-0 cyclopentane-1,2-dione 
• 1056246-36-6 2-bromocyclopentanone 
• 339362-68-4 2-aminocyclopentanone 
• 120-92-3 cyclopentanone 
• 68522-02-1 1-Azido-1-cyclopenten 
• 694-28-0 2-chlorocyclopentanone 

Relevant academic research and scientific papers

Ligustrazine-fused cyclic compound and medicine composition thereof, as well as application in medicine thereof

The invention discloses a ligustrazine-fused cyclic compound and a medicine composition thereof and application in a medicine. The ligustrazine-fused cyclic compound has the following structural general formula I: as shown in the specification. The medicine composition is a medicinal active component for the ligustrazine-fused cyclic compound and a pharmaceutically acceptable carrier, an excipient, a diluent, an adjuvant, a medium or a combination thereof; the ligustrazine-fused cyclic compound and the medicine composition can be used for preventing or treating cardiovascular and cerebrovascular diseases, digestive system diseases, respiratory diseases, the alzheimer's disease, kidney diseases and complications of the above-mentioned diseases due to thrombus and excessive free radicals. The ligustrazine-fused cyclic compound disclosed by the invention has an extremely good inhibition effect on in vitro ADP (adenosine diphosphate)-induced platelet aggregation; meanwhile, compared with the pharmacokinetic property of ligustrazine serving as a female parent, the pharmacokinetic property of the ligustrazine-fused cyclic compound in the body of a rat is obviously improved.

Phosphine Supported Ruthenium Nanoparticle Catalyzed Synthesis of Substituted Pyrazines and Imidazoles from α-Diketones

A new methodology has been developed for the synthesis of highly substituted nitrogen heterocycles such as pyrazines and imidazoles starting from α-diketones using phosphine supported ruthenium nanoparticles (RuNPs) as catalysts. Ruthenium nanoparticles Ru1-Ru4 supported with different phosphines such as dbdocphos, dppp, DPEphos, and Xantphos are screened, of which Ru1 and Ru4 are found to be the most active. Interestingly, aryl-substituted and alkyl-substituted α-diketones produced different products: namely, pyrazine and imidazoles, respectively. This reaction methodology has been applied to the synthesis of a key intermediate (2m) of the marine cytotoxic natural product Dragmacidin B and an estrogen receptor (2l). This work represents the first examples of pyrazines prepared by RuNPs.

The reaction of α-halocarbonyl compounds with (NH4)OH, (NH4)So4 or NH4CI solution under microwave-irradiation

Reaction of α-halo ketone (a-bromo ketone) under microwave, irradiation gives the pyrazine and quinoxaline derivative in good yields. This reaction affords a clean and convenient synthetic method for pyrazine and quinoxaline derivatives.

Synthesis and reactions of highly strained 2,3-bridged 2H-azirines

Take the strain: Despite extreme ring strain and reactivity, the heterocycles 2, which are easily obtained from azides 1 and detectable by NMR spectroscopy, can be converted stereoselectively by novel addition and cycloaddition reactions. (Chemical Equation Presented)

Microwave-assisted synthesis of α-hydroxy ketone and α-diketone and pyrazine derivatives from α-halo and α,α′-dibromo ketone

A novel reaction of α-halo ketone (α-bromo and α-chloro ketone) with irradiation under microwave gave the corresponding α-hydroxyketone and pyrazine derivative in good yields. In the case of α,α′-dibromo ketone, α-diketone was obtained. This reaction affords a new, clean and convenient synthetic method for α-hydroxyketone, α-diketone, α-chloro ketone and pyrazine derivative.

ONE STEP SYNTHESIS OF BICYCLOALKAPYRAZINES USING DINITRILES WITH LOW-VALENT TITANIUM

Preparative methods of obtaining bicycloalkapyrazines (2) by the low-valent titanium induced reductive cyclization of dinitriles (1), and for obtaining bi(azacycloalka)pyrazines (5) from N,N-bis(2-cyanoethyl)aromatics amines (4) are presented.