31590-01-9Relevant academic research and scientific papers
Synthesis and antimicrobial activity of some new triazino-, triazolo-, and pyrazolopyridazine derivatives
Yassin
body text, p. 997 - 1003 (2010/04/03)
The reaction of 3-hydrazino-4,5,6-triphenylpyridazine with phenacyl bromide afforded triazolopyridazine, while the reaction with different aldehydes gave the corresponding 3-arylidene hydrazinopyridazine derivatives which, on reaction with Br2/
Reactions of Grignard Reagents with 4-Cyano-5,6-diphenyl and -6-p-Tolyl-3(2H)-pyridazinones and 6-p-Tolyl-3(2H)-pyridazinethione
Jahine, H.,Zaher, H. A.,Sherif, O.,Seada, M.
, p. 502 - 503 (2007/10/02)
4-Cyano-5,6-diphenyl-3(2H)-pyridazinone (I) reacts with phenylmagnesium bromide to give 4-benzoyl-4,5,6-triphenyl-4,5-dihydro-3(2H)-pyridazinone (II) and 4,5,6-triphenyl-3(2H)-pyridazinone (III).Reaction of 6-p-tolyl-3(2H)-pyridazinone (IV) with phenylmagnesium bromide in THF-ether gives 5-phenyl-6-p-tolyl-4,5-dihydro-3(2H)-pyridazinone (V) and with arylmagnesium bromides in benzene affords 4-aryl-6-tolyl-3(2H)-pyridazinones (IVb-d). 6-p-Tolyl-3(2H)-pyridazinethione (VIa) reacts with arylmagnesium bromides in benzene or THF-ether to give 4-aryl-6-p-tolyl-3(2H)-pyridazinethiones (VIb,c).
Antihypertensive 5,6-diarylpyridazin-3-ones
Buchman,Scozzie,Ariyan,Heilman,Rippin,Pyne,Powers,Matthews
, p. 1398 - 1405 (2007/10/02)
The synthesis of a series of 5,6-diarylpyridazinones is described. Some members of this series display an antihypertensive effect in both the spontaneously hypertensive rat model and the deoxycorticosteroid (DOCA) model of hypertension. The most potent co
Antihypertensive pyridazin(2H)-3-ones
-
, (2008/06/13)
Compounds of the formula STR1 are useful antihypertensive agents.
