79225-55-1

Usage

Uses

Used in Medicinal Chemistry:
2,3-Dihydro-3-oxo-5,6-diphenyl-4-pyridazinecarbonitrile is used as a potential therapeutic agent for various medical conditions. Its exploration in medicinal chemistry is driven by its unique structure and the possibility of it exhibiting biological activities that could be harnessed for therapeutic purposes.
Used in Drug Discovery:
In the field of drug discovery, 2,3-Dihydro-3-oxo-5,6-diphenyl-4-pyridazinecarbonitrile is being studied for its potential to serve as a lead compound. The ongoing research aims to understand its interactions with biological targets and its potential to be developed into a drug candidate.
Used in Organic Synthesis:
2,3-Dihydro-3-oxo-5,6-diphenyl-4-pyridazinecarbonitrile is also being examined for its chemical reactivity, which could make it a valuable intermediate in organic synthesis. Its potential use in the synthesis of other complex molecules is an area of active research within the chemical community.

InChI:InChI=1/C17H11N3O/c18-11-14-15(12-7-3-1-4-8-12)16(19-20-17(14)21)13-9-5-2-6-10-13/h1-10H,(H,20,21)

Upstream product

• 105-56-6 ethyl 2-cyanoacetate 
• 134-81-6 benzil 
• 140-87-4 Cyanoacetohydrazide 
• 5344-88-7 benzil monohydrazone 
• 107-91-5 cyanoacetic acid amide 
• 134129-61-6 3,4-diphenyl-5-cyano-6-(ethoxycarbonylmethylthio)pyridazine 
• 54525-41-6 2-cyano-4-oxo-3,4-diphenyl-crotonic acid ethyl ester 

Downstream Products

• 31590-01-9 4,5,6-triphenyl-3(2H)-pyridazinone 
• 79225-56-2 4-Benzoyl-4,5,6-triphenyl-4,5-dihydro-3(2H)-pyridazinone 
• 92453-88-8 4-benzoyl-5,6-diphenylpyridazine-3(2H)-one 
• 112450-36-9 5,6-diphenyl-4-(1,1-diphenyl-1-hydroxymethyl)-2,3-dihydropyridazin-3-one 
• 108633-48-3 5,6-diphenyl-4-propionoyl pyridazin-3(2H)-one 
• 128462-40-8 ethyl 5-amino-3,4-diphenylfuro<2,3-c>pyridazine-6-carboxylate 
• 132165-63-0 1-benzenesulphonyl-3,4-diphenyl-5-cyanopyridazin-6-one 
• 132165-68-5 1-p-toluenesulphonyl-3,4-diphenyl-5-cyanopyridazin-6-one 
• 141238-67-7 5-amino-3,4-diphenylfuro<2,3-c>pyridazine-6-carboxamide 
• 94011-79-7 3-chloro-5,6-diphenylpyridazine-4-carbonitrile 
• 112450-34-7 4-cyano-5,6-diphenylpyridazine-3 (2H)-thione 
• 107042-54-6 5-amino-3,4-diphenyl-7H-pyrazolo-<3,4-c>-pyridazine 
• 82232-20-0 Ethyl (5-cyano-3,4-diphenyl-6-oxo-1,6-dihydropyridazin-1-yl)acetate 
• 82231-91-2 3-oxo-5,6-diphenyl-2,3-dihydro-pyridazine-4-carboxylic acid 

Relevant academic research and scientific papers

Synthesis of new annulated pyridazine derivatives and studying their antioxidant and antimicrobial activities

Benzil was reacted with cyanoacetohydrazide under microwave irradiation to give 3-oxo-5,6-diphenyl-2,3-dihydropyridazine-4-carbonitrile 1 which used as starting material for the synthesis of new heterocyclic compounds. Chlorination of pyridazinone 1 with

Synthesis of Diphenyl Pyridazinone-based flexible system for conformational studies through weak noncovalent interactions: Application in DNA binding

This paper reports conformational studies of pyridazinone-based flexible dimer connected through diethylamine linker. The conformational studies have been done by X-ray crystal structure and DFT calculation. Further, after crystallization, the compound has shown two types of crystals, one is hydrated and another one is non-hydrated. The hydrated and non-hydrated crystals showed difference in their conformation due to the presence of water in crystal lattice of hydrated crystal. The difference in their conformation has been proved by crystallographic studies, DSC curves and detailed analysis of Hirshfeld surfaces and fingerprint plots facilitating a comparison of intermolecular interactions. Along with conformational studies, this compound also showed DNA binding, as revealed in docking simulation studies.

CCSO nano catalyzed solid phase synthesis of 3-oxo-5,6-disubstituted-2,3-dihydropyridazine-4-carbonitrile

Co-doped Ce0.94Ca0.05Sr0.01O1.94 (CCSO) nano particles have been successfully synthesized by an auto-combustion method and were characterized by XRD, TEM and AFM analyses. The catalytic activity of the nano-catalyst is evaluated by the synthesis of substituted pyridazines from substituted benzil and cyano acetylhydrazide, which have great biological and pharmaceutical interest. Thus, a highly economically efficient one-pot solvent free synthesis of pyridazine was developed, which is promoted by the CCSO nano catalyst. The benefits of the reaction are its very short time (2-4 min) and high yields (90-95%). The method offers a highly convergent, inexpensive, and functionality-tolerable procedure for rapid access to important pyridazine compounds in good yields. This journal is

Pyridazine derivatives and related compounds, part 28.1 pyridazinesulfonamides: Synthesis and antimicrobial activity

The reaction of 3-chloropyridazine 1 with N -(un)Substituted 4-aminosulfonamides 3 gave the 3-substituted aminopyridazines 4. Also In addition, pyridazine-3-sulfonamides 7 were prepared from the reaction of pyridazine-3-sulfonylchloride 6 with different amines. All of these derivatives have been characterized by analytical and spectroscopic studies, and also were tested for their in vitro antibacterial and antifungal activity against a variety of microorganisms.

BENZIL IN HETEROCYCLIC SYNTHESIS: SYNTHESIS AND REACTIONS OF 3,4-DIPHENYL-5-CYANO-PYRIDAZINE-6-THIONE

3,4-Diphenyl-5-cyanopyridazine-6-thione (7) is prepared via three routes either by the reaction of benzil hydrazone (1) and cyanothioacetamide (2) or by the reaction of benzil (3) with cyanothioacetamide to give (4) which reacts with hydrazine hydrate to give the intermediate (5) that cyclised to (7) by boiling with glacial acetic acid or by the action of P2S5 on 3,4-diphenyl-5-cyanopyridazin-6-one (6).Methylation of the SH group in (7) afforded (8) while its reaction with ethyl bromoacetate gave the pyridazine derivative (9).Treatment of (8) and (9) with hydrazine hydrate produced directly the pyrazolopyridazine derivative (10).Treatment of (9) with NH3/EtOH afforded the amidic derivative (11) while its treatment with dil.HCl gave 3,4-diphenyl-5-cyanopyridazin-6-one (6).Treatment of (9) with NH3/heat then acidification gave carboxylic derivative (12).Treatment of (9) with p-chloroaniline and p-toluidine gave p-chloroanilino and toluidino derivatives (13a,b).Keywords: Pyridazine-6-thiones; synthesis, reactions IR and 1H-NMR.

Herbicidal and plant growth regulant diphenylpyridazinones

Novel compounds of the general formula STR1 as well as novel compositions thereof and methods of using same are described. These compounds have been found to be valuable for controlling, modifying and inhibiting the growth of plants.