31608-26-1Relevant articles and documents
[...] and its preparation method (by machine translation)
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Paragraph 0057; 0062; 0065; 0067; 0068; 0069, (2018/03/24)
The invention discloses a high-purity [...] and its preparation method; its preparation as follows: cyclopentanone and P-formaldehyde condensation reaction to obtain the exocyclic double bond of the α, β - unsaturated ketone (II); then and methylation reagent reaction to obtain the α ', α' - double-methyl substituted exocyclic double bond of the α, β - unsaturated ketone (III); then under the action of catalyst and hydrogen reduction of the double bond is obtained by reaction of 2, 2 - dimethyl - 5 - (4 - benzylic) cyclopentanone (IV); the reduction product (IV) generating Johnson - Corey - Chaykovsky reaction to obtain the epoxy propane compound (V); finally the epoxy propane compounds (V) and 1, 2, 4 - triazole reaction and after recrystallized to obtain high-purity [...] (I). Preparation method of this invention the raw material is cheap, short route, good selectivity, high total yield, good atom economy advantages, is extremely suitable for industrial production. (by machine translation)
Ultrasound mediation for efficient synthesis of monoarylidene derivatives of homo- and heterocyclic ketones
Mojtahedi, Mohammad M.,Abaee, M. Saeed,Samianifard, Mehdieh,Shamloo, Akram,Padyab, Masoomeh,Mesbah, A. Wahid,Harms, Klaus
, p. 924 - 930 (2013/03/13)
Ultrasonic irradiation was efficiently used for high yield synthesis of monoarylidene derivatives of cyclic systems directly from the reaction of ketone with various aldehydes under solvent-free conditions. Reactions took place rapidly in the presence of catalytic amounts of pyrrolidine, while no significant formation of the undesired bis by-products was observed. Moreover, the procedure was applicable to both homo- and heterocyclic ketones.
2-METHYLENE-5-SUBSTITUTED-METHYLENECYCLOPENTANONE DERIVATIVES AND USE THEREOF
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Page/Page column 3, (2011/04/18)
The invention relates to 2-methylene-5-substituted-methylenecyclopentanone derivatives of formula I, and the use thereof. The derivatives of formula I as active components are useful for preparing a medicine for the treatment and/or prevention of cancer diseases such as breast cancer, lung cancer, colon cancer, rectal cancer, stomach cancer, prostate cancer, bladder cancer, uterus cancer, pancreatic cancer and ovary cancer. The active compounds of the invention may be used as an anticancer drug alone or used in combination with one or more other antitumor drugs. A combined therapy can be carried out by administrating each therapeutic component concurrently, subsequently or separately.