316362-07-9Relevant articles and documents
Modular access to heterocycles: Methyl 3-aminobenzo[b]thiophene-2- carboxylate-thiourea linkage or pyrimidine-4-one-2-thione formation
Rousseau, Jolanta,Krisciuniene, Vilija,Rimkeviciute, Ilona,Rousseau, Cyril,Amankaviciene, Virgine,Sackus, Algirdas,Tatibouet, Arnaud,Rollin, Patrick
experimental part, p. 339 - 348 (2010/04/26)
Modular conditions for the formation of thioureas or pyrimidine-4-one-2- thiones connected to the benzo[b]thiophene, benzene and indole structures were performed. A benzo[b]thiophene isothiocyanate derivative was used as a model to study the condensation with simple aromatic amines and amino-l-sorbose derivative. The construction of pyrimidine-4-one-2-thiones using basic conditions afforded efficiently new heterocyclic aromatics, which were further transformed using the alkylated sulfur as a leaving group in palladium-catalyzed cross-coupling reactions.
A convenient 'catch and release' synthesis of fused 2-alkylthio-pyrimidinones mediated by polymer-bound BEMP
Adams, Gregory L.,Graybill, Todd L.,Sanchez, Robert M.,Magaard, Victoria W.,Burton, George,Rivero, Ralph A.
, p. 5041 - 5045 (2007/10/03)
A robust 'catch and release' synthesis of fused 2-alkylthio-3-substituted-pyrimidinones mediated by the polymer-bound base P-BEMP is described. This reengineered synthesis combines the efficiency of the classical synthesis (three steps, three diversity points) with the practical benefits of resin-bound reagents. The solution-phase strategy, reagent compatibility, and the results of a representative 48-member combinatorial library are described and presented herein.
