31638-96-7

Usage

Uses

Used in Pharmaceutical Industry:
3,4,5-Trimethoxy-N-3-pyridylbenzamide is used as an intermediate compound for the preparation of iridium benzoylaminopyridinium complex. This complex is of significant interest in the pharmaceutical industry due to its potential applications in the development of new drugs, particularly those targeting cancer cells. The unique structure of 3,4,5-trimethoxy-N-3-pyridylbenzamide allows for the formation of stable complexes with iridium, which can be further explored for their therapeutic properties.

InChI:InChI=1/C15H16N2O4/c1-19-12-7-10(8-13(20-2)14(12)21-3)15(18)17-11-5-4-6-16-9-11/h4-9H,1-3H3,(H,17,18)

Upstream product

• 118-41-2 Eudesmic acid 
• 462-08-8 pyridin-3-ylamine 
• 4521-61-3 3,4,5-Trimethoxybenzoyl chloride 

Downstream Products

• 30751-05-4 troxipide 

Relevant academic research and scientific papers

A mesoionic nitrogen-donor ligand: Structure, iridium coordination, and catalytic effects

A mesoinic pyridylideneamide ligand (PYA) was synthetized and fully characterized and coordinated to an iridium(iii) center. This ligand represents the first example of a mesoionic N-donor ligand. Structural and spectroscopic analysis revealed unique properties which were exploited in chemically driven water oxidation catalysis.

Troxipide preparation method

The invention belongs to the field of pharmaceutical chemical synthesis and relates to a troxipide preparation method. The preparation method includes steps: 1) preparing 3,4,5-triethoxy benzoyl chloride from 3,4,5-trimethoxybenzoic acid and triphosgene in an organic solvent under the catalytic action of an amine catalyst, subjecting to condensation reaction with 3-aminopyridine in an organic solvent in existence of inorganic base, and performing aftertreatment to obtain 3,4,5-triethoxy-N-3-pyridylbenzamide; 2) subjecting the 3,4,5-triethoxy-N-3-pyridylbenzamide to catalytic hydrogenation to obtain a crude product of troxipide, and refining to obtain troxipide. The troxipide preparation method has advantages of easiness in raw material acquisition, short reaction steps, mild conditions, simplicity in aftertreatment, high product quality, high purity and suitableness for industrial production.