316382-53-3

Usage

Uses

Used in Pharmaceutical Industry:
2,3-Dichloro-α-(2,3-dichloro-4-Methoxyphenyl)-4-Methoxy-benzeneacetic Acid Ethyl Ester is used as an intermediate in the synthesis of ethylidenebisaripiprazole, a compound with potential applications in the treatment of various psychiatric disorders. Its role in the synthesis process is crucial for the development of new medications that can help improve the quality of life for patients suffering from such conditions.
Used in Chemical Synthesis:
In the broader chemical industry, 2,3-Dichloro-α-(2,3-dichloro-4-Methoxyphenyl)-4-Methoxy-benzeneacetic Acid Ethyl Ester may also serve as a building block for the creation of other complex organic molecules. Its unique structure allows for further functionalization and modification, making it a valuable component in the synthesis of a wide range of chemical products.

Upstream product

• 924-44-7 glyoxylic acid ethyl ester 
• 1984-59-4 2,3-dichloroanisole 

Downstream Products

• 476014-22-9 2,2-bis-(2,3-dichloro-4-methoxy-phenyl)-ethanol 
• 397301-38-1 C₁₆H₁₃BrCl₄O₂ 

Relevant academic research and scientific papers

Aldehyde bis-arylation by metal triflates including bismuth triflate powder

Development of an efficient catalytic reaction promoted by a metal triflate has been emphasized in contemporary synthesis. To evaluate the potential of some metal trflates such as bismuth triflate in our process research, we devised here an expedient protocol for its preparation and characterization. Comparison of its catalytic activity with other well-known metal triflates such as scandium triflate and copper triflate was made in a glyoxylate arylation reaction, which is a useful transformation for the construction of a 1,1-diarylethane skeleton. Furthermore, NMR analysis of Bi(OTf)3 in acetone-d6 revealed the unique nature and reactivity of the triflate, which has not heretofore been disclosed.

Synthetic study on the unique dimeric arylpiperazine: Access to the minor contaminant of aripiprazole

The dimeric derivative of Aripiprazole was synthesized via the two notable synthetic technologies as a key step: (1) efficient aldehyde bis-arylation by Bi(OTf)3 and (2) facile Wynberg amination at room temperature. The synthesis has established the structural identity with the minor contaminant sometimes present in Aripiprazole.

Some aspects of NaBH4 reduction in NMP

In our solvent optimization study of NaBH4 reduction, NMP was found to enhance the reactivity. A chemoselective debromination of the bromide and sulfonates can be attained in the new borohydride reagent system: NaBH4-LiOTf-NMP. This mixed system worked as an alternative to NaBH3CN and Bu3SnH for the SN2 type displacement of alkylbromide and sulfonate. Also mentioned is an expedient reduction of an azide group into amine by NaBH4 in NMP without any additive, which offers a convenient protocol for the direct transformation of halides into amines via azide in one flask. Some examples of other reductions were also presented.