316382-53-3

Basic information

• Product Name: 2,3-Dichloro-α-(2,3-dichloro-4-Methoxyphenyl)-4-Methoxy-benzeneacetic Acid Ethyl Ester
• Synonyms: 2,3-Dichloro-α-(2,3-dichloro-4-Methoxyphenyl)-4-Methoxy-benzeneacetic Acid Ethyl Ester
• CAS NO: 316382-53-3
• Molecular Formula: C₁₈H₁₆Cl₄O₄
• Molecular Weight: 438.12924
• Product Categories: Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 316382-53-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 503.2±50.0 °C(Predicted)
• Appearance: /
• Density: 1.376±0.06 g/cm3(Predicted)
• Solubility: Chloroform, Dichloromethane
• CAS DataBase Reference: 2,3-Dichloro-α-(2,3-dichloro-4-Methoxyphenyl)-4-Methoxy-benzeneacetic Acid Ethyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-Dichloro-α-(2,3-dichloro-4-Methoxyphenyl)-4-Methoxy-benzeneacetic Acid Ethyl Ester(316382-53-3)
• EPA Substance Registry System: 2,3-Dichloro-α-(2,3-dichloro-4-Methoxyphenyl)-4-Methoxy-benzeneacetic Acid Ethyl Ester(316382-53-3)

Safety Data

• Hazardous Substances Data: 316382-53-3(Hazardous Substances Data)

Usage

Uses

2,3-Dichloro-α-(2,3-dichloro-4-methoxyphenyl)-4-methoxy-benzeneacetic Acid Ethyl Ester is an intermediate in the preparation of ethylidenebisaripiprazole.

Upstream product

• 1984-59-4 2,3-dichloroanisole 
• 924-44-7 glyoxylic acid ethyl ester 

Downstream Products

• 397301-38-1 C₁₆H₁₃BrCl₄O₂ 
• 476014-22-9 2,2-bis-(2,3-dichloro-4-methoxy-phenyl)-ethanol 

Relevant articles and documents

Aldehyde bis-arylation by metal triflates including bismuth triflate powder

Development of an efficient catalytic reaction promoted by a metal triflate has been emphasized in contemporary synthesis. To evaluate the potential of some metal trflates such as bismuth triflate in our process research, we devised here an expedient protocol for its preparation and characterization. Comparison of its catalytic activity with other well-known metal triflates such as scandium triflate and copper triflate was made in a glyoxylate arylation reaction, which is a useful transformation for the construction of a 1,1-diarylethane skeleton. Furthermore, NMR analysis of Bi(OTf)3 in acetone-d6 revealed the unique nature and reactivity of the triflate, which has not heretofore been disclosed.

Some aspects of NaBH4 reduction in NMP

In our solvent optimization study of NaBH4 reduction, NMP was found to enhance the reactivity. A chemoselective debromination of the bromide and sulfonates can be attained in the new borohydride reagent system: NaBH4-LiOTf-NMP. This mixed system worked as an alternative to NaBH3CN and Bu3SnH for the SN2 type displacement of alkylbromide and sulfonate. Also mentioned is an expedient reduction of an azide group into amine by NaBH4 in NMP without any additive, which offers a convenient protocol for the direct transformation of halides into amines via azide in one flask. Some examples of other reductions were also presented.