3164-07-6

Usage

Uses

Used in Pharmaceutical Industry:
4-(Benzo[d]oxazol-2-yl)-2-Methoxyphenol is used as a therapeutic agent for its potential anti-inflammatory and antioxidant effects. It is being studied for its potential use in the development of new drugs for various medical conditions.
Used in Materials Science:
In the field of materials science, 4-(Benzo[d]oxazol-2-yl)-2-Methoxyphenol is used for its potential application in the development of new polymers. Its unique structure and properties make it a candidate for creating innovative materials with specific characteristics.
Used as a Fluorescent Dye:
4-(Benzo[d]oxazol-2-yl)-2-Methoxyphenol is also being investigated for its potential use as a fluorescent dye in biological imaging applications. Its fluorescent properties can be harnessed to enhance the visualization of biological processes and structures.

InChI:InChI=1/C14H11NO3/c1-17-13-8-9(6-7-11(13)16)14-15-10-4-2-3-5-12(10)18-14/h2-8,16H,1H3

Upstream product

• 51821-39-7 N**2-(3-methoxy-4-hydroxybenzylidene)aminophenol 
• 1236771-62-2 2-[4-(benzyloxy)-3-methoxyphenyl]-1,3-benzoxazole 
• 121-34-6 3-methoxy-4-hydroxybenzoic acid 
• 95-55-6 2-amino-phenol 

Downstream Products

• 540497-27-6 4-(1,3-benzoxazol-2-yl)-2-methoxyphenyl trifluoromethanesulfonate 
• 1049018-59-8 (2S)-N-{4-(N-[4-(1,3-benzoxazole-2-yl)-2-methoxyphenoxy]pentyl)oxy-5-methoxy-2-nitrobenzoyl}-pyrrolidine-2-carboxaldehyde diethylthioacetal 
• 1236771-72-4 2-[4-(5-bromopentyloxy)-3-methoxyphenyl]-1,3-benzoxazole 

Relevant academic research and scientific papers

Facile one-pot synthesis of (benzoxazol-2'-yl)bicyclo[2.2.2]octen-2-one derivatives

Abstract A simple and efficient one-pot synthesis of 5-(benzoxazol-2'-yl)bicyclo[2.2.2]octen-2-one derivatives from readily accessible starting materials has been demonstrated. The current protocol involves diacetoxyiodobenzene mediated domino oxidative c

ALIGNMENT COMPOUNDS

The present invention relates to compounds represented by the following Formula (I). With reference to Formula (I), at least one of E1 and E2 independently is, or is independently substituted with, at least one reactive group, such as a (meth)acryloyl group. The compounds of the present invention can be used alone and/or in combination with polymers prepared from such compounds, such as to form or as one or more components of an alignment layer.

Synthesis, DNA-binding ability and anticancer activity of benzothiazole/benzoxazole-pyrrolo[2,1-c][1,4]benzodiazepine conjugates

A series of benzothiazole and benzoxazole linked pyrrolobenzodiazepine conjugates attached through different alkane or alkylamide spacers was prepared. Their anticancer activity, DNA thermal denaturation studies, restriction endonuclease digestion assay and flow cytometric analysis in human melanoma cell line (A375) were investigated. One of the compounds of the series 17d showed significant anticancer activity with promising DNA-binding ability and apoptosis caused G0/G1 phase arrest at sub-micromolar concentrations. To ascertain the binding mode and understand the structural requirement of DNA binding interaction, molecular docking studies using gold program and more rigorous 2 ns molecular dynamic simulations using Molecular Mechanics-Poisson-Boltzman Surface Area (MM-PBSA) approach including the explicit solvent were carried out. Further, the compound 17d was evaluated for in vivo efficacy studies in human colon cancer HT29 xenograft mice.

Discovery of novel modulators of metabotropic glutamate receptor subtype-5

A series of potent and selective mGluR5 antagonists were synthesized and evaluated in vitro and in vivo. It was found that a pyridyl functionality is a potential replacement for acetonitrile in the lead structure, with 2-pyridyl being most favored. Additi