31645-22-4Relevant academic research and scientific papers
Nickel-Catalyzed Aminoxylation of Inert Aliphatic C(sp3)-H Bonds with Stable Nitroxyl Radicals under Air: One-Pot Route to α-Formyl Acid Derivatives
Wang, Chunxia,Zhang, Luoqiang,You, Jingsong
supporting information, p. 1690 - 1693 (2017/04/11)
Nickel-catalyzed aminoxylation of an unactivated C(sp3)-H bond with a stable nitroxyl radical has been accomplished for the first time to offer various N-alkoxyamine derivatives, which further enables a one-pot approach to α-formyl acid derivatives. The aminoxylation process reported also provides direct evidence for the oxidative addition of a cyclometallic intermediate with a free radical, which is helpful for the reaction-mechanism study in transition-metal-catalyzed functionalization of inert C(sp3)-H bonds.
THE USE OF STABLE LIPOPHILIC HYDROXYLAMINE COMPOUNDS FOR INHIBITING POLYMERIZATION OF VINYL MONOMERS
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Page/Page column 12; 13, (2016/10/04)
The present invention generally relates to compounds and methods for inhibiting the radical polymerization of unsaturated compounds, particularly vinyl monomers. More particularly, it relates to the use of stable hydroxyl amines to inhibit the polymerization of unsaturated compounds (e.g., vinyl monomers) wherein said stable hydroxylamine is soluble in organic solvents, particularly hydrocarbon solvents consisting of unsaturated and, therefore, polymerizable constituents.
A novel protecting group methodology for syntheses using nitroxides
Chalmers, Benjamin A.,Morris, Jason C.,Fairfull-Smith, Kathryn E.,Grainger, Richard S.,Bottle, Steven E.
supporting information, p. 10382 - 10384 (2013/10/22)
The methoxyamine group represents an ideal protecting group for the nitroxide moiety. It can be easily and selectively introduced in high yield (typically >90%) to a range of functionalised nitroxides using FeSO 4·7H2O and H2O2 in DMSO. Its removal is readily achieved under mild conditions in high yield (70-90%) using mCPBA in a Cope-type elimination process.
HYDROXYLAMINE COMPOUNDS AND METHODS OF THEIR USE
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Page/Page column 78, (2008/12/08)
The present disclosure provides compounds that include hydroxylamines of formula (I) or (II), pharmaceutical compositions, and methods for their use. The methods utilize hydroxylamine compounds and/or their pharmaceutical compositions for the treatment of angiogenesis, hepatitis, complement-mediated pathologies, drusen-mediated pathologies, macular degeneration and certain other ophthalmic conditions, inflammation, arthritis, and related diseases and for the inhibition of complement activation.
Drug Resistance Reversal In Neoplastic Disease
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Page/Page column 35, (2008/12/08)
The present invention is directed to compounds, compositions, and methods for halting or reversing the effects of chemoresistance in neoplastic diseases. In particular the use of hydroxylamines is described.
Synthesis and enzyme-catalyzed hydrolysis of a radical-masked glycosylated spin-label reagent
Sato, Shingo,Nemoto, Miho,Kumazawa, Toshihiro,Matsuba, Shigeru,Onodera, Jun-Ichi,Aoyama, Masaaki,Obara, Heitaro,Kamada, Hitoshi
, p. 2425 - 2432 (2007/10/03)
N1-Acetoxy-2,2,6,6-tetramethylpiperidin-4-yl 2,3,4,6-tetra-O-benzyl-α- and -β-d-glucopyranosides (3-α, β) and N1-acetoxy-2,2,5,5-tetramethylpyrrolin-3-oyl 2,3,4,6-tetra-O-benzyl-α- and -β-d-glucopyranosylamines (9-α, β) were synthesized in good yield by Schmidt's glycosylation method. Their subsequent O-debenzylation was proceeded successfully to give the desired products 1-α, and 1-β in good yield, and 2-α in a low yield, without 2-β by only short-timed hydrogenolysis in the presence of palladium-on-carbon (Pd-C) in a CHCl3-MeOH solvent system that included concentrated HCl. Upon enzyme-catalyzed hydrolysis, only 2-α was hydrolyzed by the esterase, while both of 1-α and 1-β were not hydrolyzed by any other enzyme such as lipase. These 2-α can likely be used as a new water-soluble radical-masked glycosylated spin-label reagent.
