31685-80-0Relevant articles and documents
Pinusolidic Acid: A Platelet-Activating Factor Inhibitor from Biota orientalis
Yang, Hyun Ok,Han, Byung Hoon
, p. 73 - 74 (1998)
The water extract of Biota orientalis showed a potent inhibitory effect on platelet activating factor (PAF) binding to rabbit platelets using PAF as a ligand in our previous screeening studies for Korean medicinal antagonists by the activityguided purification studies.Another active compound, compound 1 (IC50=2.3*10-5 M, 7.48 +/- 2.11 μg/ml, n=4) was isolated from the title plant.The chemical structure of compound 1 was elucidated as pinusolidic acid by chemical and spectrometric analyses.
Gram-scale synthesis of pinusolide and evaluation of its antileukemic potential
Shults,Velder,Schmalz,Chernov,Rubalova,Gatilov,Henze,Tolstikov,Prokop
, p. 4228 - 4232 (2007/10/03)
Pinusolide (1), a known platelet-activating factor (PAF) receptor binding antagonist, was synthesized from lambertianic acid (2), a labdane-type diterpene readily accessible in multigram quantities from the Siberian pine tree. It was shown that 1 not only decreases the proliferation activity of tumor cells at relatively low concentrations but specifically induces apoptosis at 100 μM via the mitochondrial pathway in the Burkitt lymphoma cell line BJAB. Also, using primary lymphoblasts and leukemic cells from children with acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML), a significant DNA fragmentation in pinusolide-treated cells could be detected in an ex vivo apoptosis assay.
