Pinusolidic Acid: A Platelet-Activating Factor Inhibitor from Biota orientalis

Article abstract of DOI:10.1055/s-2006-957371

The water extract of Biota orientalis showed a potent inhibitory effect on platelet activating factor (PAF) binding to rabbit platelets using <3H>PAF as a ligand in our previous screeening studies for Korean medicinal antagonists by the activityguided purification studies.Another active compound, compound 1 (IC50=2.3*10^-5 M, 7.48 +/- 2.11 μg/ml, n=4) was isolated from the title plant.The chemical structure of compound 1 was elucidated as pinusolidic acid by chemical and spectrometric analyses.