31689-12-0Relevant academic research and scientific papers
Use of ruthenium/alumina as a convenient catalyst for copper-free Sonogashira coupling reactions
Park, Soyoung,Kim, Min,Dong, Hyun Koo,Chang, Sukbok
, p. 1638 - 1640 (2004)
It has been found that a new and practical catalyst system of ruthenium-supported on alumina carries out copper-free Sonogashira coupling reactions with high efficiency over a wide range of substrates under mild and convenient conditions.
Palladium-catalyzed coupling of aryl halides with alkynes
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Page/Page column 6-10, (2010/02/16)
A method is provided to couple an aryl halide to an alkyne comprising reacting a compound of the formula ArX, wherein Ar is a substituted or unsubstituted aryl group and X is I or Br, with a compound of the formula HC≡C—R1 wherein R1 /sup
High throughput evaluation of the production of substituted acetylenes by the Sonogashira reaction followed by the Mizoroki-Heck reaction in ionic liquids, in situ, using a novel array reactor
Rahman, Md. Taifur,Fukuyama, Takahide,Ryu, Ilhyong,Suzuki, Kanae,Yonemura, Koichi,Hughes, Philip F.,Nokihara, Kiyoshi
, p. 2703 - 2706 (2007/10/03)
The parallel Sonogashira coupling reaction was carried out under copper-free condition by integrating the advantages of ionic liquids as the reaction media followed by the simultaneous-multiple Mizoroki-Heck reaction in situ by the use of a novel array re
Ligand-, copper-, and amine-free sonogashira reaction of aryl iodides and bromides with terminal alkynes
Urgaonkar, Sameer,Verkade, John G.
, p. 5752 - 5755 (2007/10/03)
Conditions for an efficient ligand-, copper-, and amine-free palladium-catalyzed Sonogashira reaction of aryl iodides and bromides with terminal alkynes have been developed. Critical to the success of this new protocol is the use of tetrabutylammonium ace
Sonogashira coupling using bulky palladium-phenanthryl imidazolium carbene catalysis
Ma, Yudao,Song, Chun,Jiang, Wei,Wu, Quansheng,Wang, Yong,Liu, Xueying,Andrus, Merritt B.
, p. 3317 - 3319 (2007/10/03)
(Matrix presented) Bulky phenanthracenyl imidazolium-derived carbene ligands were investigated for copper-free Sonogashira coupling with terminal acetylenes. Aryl bromides and iodides gave coupled products in excellent yields from the Pd(PPh3)2Cl2 complex with potassium t-butoxide and 18-crown-6 in THF. A remarkable dependence on the size of the ligand was found. The highest yields were obtained with the bulky 2,9-dicyclohexyl-10-phenanthryl ligand 5.
