317319-28-1

Basic information

• Product Name: 5-(CHLOROMETHYL)-2-(4-CHLOROPHENYL)-4-METHYL-1,3-THIAZOLE
• Synonyms: 5-(CHLOROMETHYL)-2-(4-CHLOROPHENYL)-4-METHYL-1,3-THIAZOLE
• CAS NO: 317319-28-1
• Molecular Formula: C₁₁H₉Cl₂NS
• Molecular Weight: 258.17
• Mol File: 317319-28-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 109-112°C
• Boiling Point: 389.7°Cat760mmHg
• Flash Point: 189.5°C
• Appearance: /
• Density: 1.335g/cm³
• Vapor Pressure: 6.28E-06mmHg at 25°C
• Refractive Index: 1.607
• CAS DataBase Reference: 5-(CHLOROMETHYL)-2-(4-CHLOROPHENYL)-4-METHYL-1,3-THIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(CHLOROMETHYL)-2-(4-CHLOROPHENYL)-4-METHYL-1,3-THIAZOLE(317319-28-1)
• EPA Substance Registry System: 5-(CHLOROMETHYL)-2-(4-CHLOROPHENYL)-4-METHYL-1,3-THIAZOLE(317319-28-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 317319-28-1(Hazardous Substances Data)

Usage

General Description

5-(Chloromethyl)-2-(4-chlorophenyl)-4-methyl-1,3-thiazole is a chemical compound with the molecular formula C11H9Cl2NS. It is a thiazole derivative that contains chloromethyl, chlorophenyl, and methyl substituents. 5-(CHLOROMETHYL)-2-(4-CHLOROPHENYL)-4-METHYL-1,3-THIAZOLE is used in pharmaceutical and agrochemical applications, and it exhibits antimicrobial and antifungal properties. It can also be used as a building block in organic synthesis for the production of other chemicals and materials. Additionally, 5-(Chloromethyl)-2-(4-chlorophenyl)-4-methyl-1,3-thiazole is considered to have potential biological activity, making it a subject of interest for research in medicinal chemistry and drug discovery.

InChI:InChI=1/C11H9Cl2NS/c1-7-10(6-12)15-11(14-7)8-2-4-9(13)5-3-8/h2-5H,6H2,1H3

Upstream product

• 2521-24-6 4-chlorothiobenzamide 
• 619-56-7 4-chlorobenzamide 
• 54001-12-6 ethyl 2-(4-chlorophenyl)-4-methyl-1,3-thiazole-5-carboxylate 
• 317319-22-5 (2-(4-chlorophenyl)-4-methylthiazol-5-yl)methanol 

Downstream Products

• 668479-82-1 [2-(4-chloro-phenyl)-4-methyl-thiazol-5-yl]-acetonitrile 
• 876147-57-8 1-(tert-butoxycarbonyl)-3-[[2-(4-chlorophenyl)-4-methylthiazol-5-yl]methoxymethyl]piperidine 
• 876148-22-0 [2-(4-chlorophenyl)-4-methylthiazol-5-yl]methyltriphenylphosphonium iodide 
• 876147-60-3 1-(tert-butoxycarbonyl)-3-[[2-(4-chlorophenyl)-4-methylthiazol-5-yl]methoxy]piperidine 
• 876148-24-2 3-[2-[2-(4-chlorophenyl)-4-methylthiazol-5-yl]ethenyl]piperidine 
• 876148-23-1 1-benzyloxycarbonyl-3-[2-[2-(4-chlorophenyl)-4-methylthiazol-5-yl]ethenyl]piperidine 
• 876147-61-4 3-[[2-(4-chlorophenyl)-4-methylthiazol-5-yl]methoxy]piperidine 

Relevant articles and documents

Discovery of first-in-class thiazole-based dual FFA1/PPARδ agonists as potential anti-diabetic agents

The free fatty acid receptor 1 (FFA1 or GPR40) and peroxisome proliferator-activated receptor δ (PPARδ) have attracted a lot of attention due to their role in promoting insulin secretion and sensibility, respectively, which are two major features of diabetes. Therefore, the dual FFA1/PPARδ agonists would increase insulin secretion and sensibility by FFA1 and PPARδ activation. In this study, we hybrid FFA1 agonist AM-4668 with PPARδ agonist GW501516, leading to the identification of orally bioavailable dual agonist 32, which revealed high selectivity over other PPARs. Moreover, compound 32 exhibited good pharmacokinetic profiles with high plasma concentration, sustained half-life and low clearance in vivo. During the hypoglycemic test, a dual agonist 32 enhanced the tolerance of ob/ob mice for glucose loading in a dose-dependent manner. Our results suggest that dual FFA1/PPARδ agonist could be a valuable therapy for type 2 diabetes.

NOVEL 2-ARYLTHIAZOLE COMPOUNDS AS PPARALPHA AND PPARGAMA AGONISTS

The present invention relates to compounds of formula (I) wherein Rl to R10, X, Y and n are as defined in the description and claims, and pharmaceutically acceptable salts and esters thereof. The compounds are useful for the treatment of diseases such as diabetes.