3178-03-8

Basic information

• Product Name: 1-Methoxy-2-naphthalenamine
• Synonyms: 1-Methoxy-2-naphthalenamine
• CAS NO: 3178-03-8
• Molecular Formula: C₁₁H₁₁NO
• Molecular Weight: 173.23
• Mol File: 3178-03-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 303.86°C (rough estimate)
• Flash Point: 170.9°C
• Appearance: /
• Density: 1.0898 (rough estimate)
• Vapor Pressure: 0.000138mmHg at 25°C
• Refractive Index: 1.4950 (estimate)
• CAS DataBase Reference: 1-Methoxy-2-naphthalenamine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methoxy-2-naphthalenamine(3178-03-8)
• EPA Substance Registry System: 1-Methoxy-2-naphthalenamine(3178-03-8)

Safety Data

• Hazardous Substances Data: 3178-03-8(Hazardous Substances Data)

Usage

Physical Appearance

Pale yellow to light brown clear liquid

Solubility

Insoluble in water, soluble in organic solvents

Primary Use

Intermediate in the production of dyes, pigments, and other organic compounds

Secondary Uses

Corrosion inhibitor in lubricating oils, manufacturing of rubber and plastics

Hazardous Nature

Potential for causing skin and eye irritation, toxicity to aquatic life

Safety Measures

Proper handling and disposal procedures must be followed for safety and environmental protection

InChI:InChI=1/C11H11NO/c1-13-11-9-5-3-2-4-8(9)6-7-10(11)12/h2-7H,12H2,1H3

Upstream product

• 2036-45-5 1-methoxy-2-phenylazo-naphthalene 
• 7647-01-0 hydrogenchloride 
• 64-17-5 ethanol 
• 64-19-7 acetic acid 
• 3375-23-3 2-phenylazo-1-naphthol 
• 607-24-9 2-nitro-1-naphthol 
• 80409-51-4 2-methoxy-1-naphthoic acid amide 
• 4900-62-3 2-nitro-1-methoxynaphthalene 

Downstream Products

• 21720-72-9 (1-methoxy-2-naphthyl)phenylamine 
• 934844-98-1 methyl 4-(1-methoxy-2-naphthylamino)benzoate 
• 604-60-4 2,2'-binaphthol 
• 151560-43-9 2-Iodo-1-methoxynaphthalene 

Relevant articles and documents

-

-

Monna, a potent and selective blocker for transmembrane protein with unknown function 16/anoctamin-1

Transmembrane protein with unknown function 16/anoctamin-1 (ANO1) is a protein widely expressed in mammalian tissues, and it has the properties of the classic calcium-activated chloride channel (CaCC). This protein has been implicated in numerous major physiological functions. However, the lack of effective and selective blockers has hindered a detailed study of the physiological functions of this channel. In this study, we have developed a potent and selective blocker for endogenous ANO1 in Xenopus laevis oocytes (xANO1) using a drug screening method we previously established (Oh et al., 2008). We have synthesized a number of anthranilic acid derivatives and have determined the correlation between biological activity and the nature and position of substituents in these derived compounds. A structure-activity relationship revealed novel chemical classes of xANO1 blockers. The derivatives contain a-NO2 group on position 5 of a naphthyl group-substituted anthranilic acid, and they fully blocked xANO1 chloride currents with an IC 5050 of 0.08 μM for xANO1. Selectivity tests revealed that other chloride channels such as bestrophin-1, chloride channel protein 2, and cystic fibrosis transmembrane conductance regulator were not appreciably blocked by 10～30 μM MONNA. The potent and selective blockers for ANO1 identified here should permit pharmacological dissection of ANO1/CaCC function and serve as potential candidates for drug therapy of related diseases such as hypertension, cystic fibrosis, bronchitis, asthma, and hyperalgesia.

OMEGA-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS

This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.