317820-44-3

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 317820-43-2 2'-O-[2-[(N,N-diethylamino)oxy]ethyl]-5-methyluridine 
• 22423-26-3 O-2,2'-cyclo-5-methyluridine 
• 317820-41-0 5'-O-tert-butyldiphenlsilyl-2'-O-[2-(acetaldoximinooxy)ethyl]-5-methyluridine 
• 212061-24-0 5'-O-(tert-butyldiphenylsilyl)-2'-O-(2-hydroxyethyl)-5-methyluridine 
• 171763-19-2 5'-O-tert-butyldiphenylsilyl-O²-2'-anhydro-5-methyluridine 

Relevant academic research and scientific papers

Synthesis of 2′-O-[2-[(N,N-dialkylamino)oxy]ethyl]-modified oligonucleotides: Hybridization affinity, resistance to nuclease, and protein binding characteristics

Synthesis of a series of 2′ -O-[2-[(N,N-dialkylamino)oxy]ethyl]-modified 5-methyluridine nucleoside phosphoramidites and solid supports are described. Using these monomers, modified oligonucleotides containing phosphodiester linkages were synthesized in h

2'-O-[2-[N,N-(dialkyl)aminooxy]ethyl]-modified antisense oligonucleotides.

[structure] Oligonucleotides with two novel modifications, 2'-O-2-[N, N-(dimethyl)aminooxy]ethyl (2'-O-DMAOE) and 2'-O-2-[N, N-(diethyl)aminooxy]ethyl (2'-O-DEAOE), have been synthesized. These modifications exhibit high binding affinity to target RNA (and not to DNA) and enhance the nuclease stability of oligonucleotides considerably with t(1/2) > 24 h as a phosphodiester.