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Thiazolo[5,4-b]pyridin-2-amine is a heterocyclic compound characterized by a unique fused ring structure that incorporates both a thiazole and a pyridine ring. Known chemically as 1,3-thiazolo[5,4-b]pyridin-2-amine, THIAZOLO[5,4-B]PYRIDIN-2-AMINE serves as a promising building block for the synthesis of a variety of biologically active molecules and pharmaceuticals. Its distinctive structural attributes, coupled with its potential medicinal properties such as antiviral and antitumor activities, render it a compelling subject for research in medicinal chemistry and pharmaceutical development.

31784-70-0

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31784-70-0 Usage

Uses

Used in Pharmaceutical Industry:
Thiazolo[5,4-b]pyridin-2-amine is utilized as a key intermediate in the synthesis of biologically active compounds for the development of new pharmaceuticals. Its unique structure and potential medicinal properties make it a valuable component in the creation of drugs with antiviral and antitumor capabilities.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, Thiazolo[5,4-b]pyridin-2-amine is employed as a subject of study to explore its diverse reactivity and pharmacological potential. Researchers are interested in understanding how its structural features can be leveraged to develop new therapeutic agents with improved efficacy and selectivity.
Used in Drug Design and Development:
Thiazolo[5,4-b]pyridin-2-amine is used as a structural template in drug design, aiming to create novel molecules with specific therapeutic targets. Its incorporation into drug candidates can potentially enhance the pharmacokinetic and pharmacodynamic profiles of new medications, leading to more effective treatments for various diseases.

Check Digit Verification of cas no

The CAS Registry Mumber 31784-70-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,1,7,8 and 4 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 31784-70:
(7*3)+(6*1)+(5*7)+(4*8)+(3*4)+(2*7)+(1*0)=120
120 % 10 = 0
So 31784-70-0 is a valid CAS Registry Number.
InChI:InChI=1/C6H5N3S/c7-6-9-4-2-1-3-8-5(4)10-6/h1-3H,(H2,7,9)

31784-70-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name [1,3]thiazolo[5,4-b]pyridin-2-amine

1.2 Other means of identification

Product number -
Other names Thiazolo[5,4-b]pyridin-2-amine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:31784-70-0 SDS

31784-70-0Relevant articles and documents

Hydrazone-based derivative, intermediate, preparation method, pharmaceutical composition and applications thereof

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Paragraph 0168-0172, (2019/10/01)

The present invention discloses a hydrazone-based derivative (I), an intermediate, a preparation method, a pharmaceutical composition and applications thereof, wherein the hydrazone-based compound hasgood inhibitory effect on the ubiquitination activity of cIAP1 protein, can promote the degradation of oncogenic protein c-MYC at a cellular level so as to inhibit the growth of tumor cells, and hasbroad drug development prospects.

Polymerizable compound, polymerizable composition, polymer, and optically anisotropic material

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Page/Page column 35, (2016/12/26)

The present invention relates to: a polymerizable compound (I), wherein Y1 to Y6 are a chemical single bond, —O—C(═O)—, —C(═O)—O— or the like, G1 and G2 are a divalent aliphatic group, Z1 and Z2 are an alkenyl group, Ax is a fused ring group represented by a formula (II), wherein X is —NR3—, an oxygen atom, a sulfur atom or the like, R3 is a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, and D is a substituted or unsubstituted ring having 1 to 20 carbon atoms that includes at least one nitrogen atom, Ay is a hydrogen atom, an alkyl group, A1 is a trivalent aromatic group or the like, A2 and A3 are a divalent aromatic group having 6 to 30 carbon atoms or the like, and Q1 is a hydrogen atom, or an alkyl group having 1 to 6 carbon atoms.

POLYMERIZABLE COMPOUND, POLYMERIZABLE COMPOSITION, POLYMER, OPTICALLY ANISOTROPIC BODY, AND METHOD FOR PRODUCING POLYMERIZABLE COMPOUND

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Paragraph 0225; 0226; 0227; 0228, (2015/07/02)

A polymerizable compound has a practical low melting point, excellent solubility in a general-purpose solvent, and can produce an optical film at low cost, exhibits low reflected luminance, and achieves uniform conversion of polarized light over a wide wavelength band, an optically anisotropic article. A carbonyl compound is useful as a raw material for producing the polymerizable compound. (In the formula (I), Y1 to Y8 represent —C(═O)—O—, G1 and G2 represent a C1-20 divalent linear aliphatic group, Z1 and Z2 represent a C2-10 alkenyl group that is unsubstituted, or substituted with a halogen atom, Ax represents a C2-30 organic group with at least one aromatic ring, Ay represents a hydrogen atom or C1-20 alkyl group, A1 represents a trivalent aromatic group, A2 and A3 represent a C3-30 divalent alicyclic hydrocarbon group, A4 and A5 represent a C6-30 divalent aromatic group or the like, and Q1 represents a hydrogen atom.)

A new method for synthesizing asymmetric urea containing thiazolo[5,4-b]pyridine and applications in agriculture

Chen, Wenbin,Li, Kejian

experimental part, p. 311 - 318 (2011/04/16)

Chemical Equation Presented In this article, we describe the use of diphenyl carbonate (DPC) as a carbonyl source instead of isocyanate to synthesize asymmetric substituted urea derivatives. In a study aiming to discover new lead compounds with agricultur

A single-step preparation of thiazolo[5,4-b]pyridine- and thiazolo[5,4-c]pyridine derivatives from chloronitropyridines and thioamides, or thioureas

Sahasrabudhe, Kiran P.,Estiarte, M. Angels,Tan, Darlene,Zipfel, Sheila,Cox, Matthew,O'Mahony, Donogh J. R.,Edwards, William T.,Duncton, Matthew A. J.

experimental part, p. 1125 - 1131 (2010/03/01)

(Chemical Equation Presented) A one-step synthesis of thiazolo[5,4-b] pyridines from an appropriately substituted chloronitropyridine and thioamide, or thiourea, is presented. In particular, the reaction was used to prepare a large number of 6-nitrothiazo

Transformations of 1-(2-Chloropyridyl-3)-4-ethoxycarbonyl- and 1-(2-Chloropyridyl-3)-4-ethoxycarbonylmethyl Thiosemicarbazides. Attempts to Prepare Pyrido-1,2,4-thiadiazine

Koren, Bozidar,Stanovnik, Branko,Tisler, Miha

, p. 333 - 340 (2007/10/02)

2-Chloro-3-hydrazinopyridine (2) was converted with ethoxycarbonyl and ethoxycarbonylmethyl isothiocyanates into 1,4-disubstituted thiosemicarbazides 3 and 4, while with phenyl isothiocyanate directly 1H-pyrido-1,3,4-thiadiazine 7 was formed.Attempts to cyclize the thiosemicarbazides 3 and 4 into pyridothiadiazine derivatives 5 and 6 failed.In the reaction of 3 with hydrazine 2-aminothiazolopyridine (9) was formed, while 4 gave only the corresponding hydrazide 10.The cyclization of the side chain occured in compound 4 by heating in aqueous hydrochloric acid to give 11, which was further transformed with N,N-dimethylformamide dimethyl acetal (DMFDMA) into 12, while with diethyl acetylene dicarboxylate the thiazolidone derivative 13 was produced. - Keywords: 1,4-Disubstituted thiosemicarbazides; 1H-Pyrido-1,3,4-thiadiazines; Thiazolidones

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