31784-70-0

Basic information

• Product Name: THIAZOLO[5,4-B]PYRIDIN-2-AMINE
• Synonyms: THIAZOLO[5,4-B]PYRIDIN-2-AMINE;[1,3]THIAZOLO[5,4-B]PYRIDIN-2-AMINE;2-AMINOTHIAZOLO[5,4-B]PYRIDINE ;Thiazolo[5,4-b]pyridin-2-ylamine
• CAS NO: 31784-70-0
• Molecular Formula: C₆H₅N₃S
• Molecular Weight: 151.19
• Mol File: 31784-70-0.mol

Chemical Properties

• Melting Point: 252-254℃ (ethanol )
• Boiling Point: 328.9ºC at 760 mmHg
• Flash Point: 152.7ºC
• Appearance: /
• Density: 1.485g/cm3
• Vapor Pressure: 0.000184mmHg at 25°C
• Refractive Index: 1.785
• Storage Temp.: 2-8°C(protect from light)
• PKA: 2.09±0.40(Predicted)
• CAS DataBase Reference: THIAZOLO[5,4-B]PYRIDIN-2-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: THIAZOLO[5,4-B]PYRIDIN-2-AMINE(31784-70-0)
• EPA Substance Registry System: THIAZOLO[5,4-B]PYRIDIN-2-AMINE(31784-70-0)

Safety Data

• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 31784-70-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Thiazolo[5,4-b]pyridin-2-amine is utilized as a key intermediate in the synthesis of biologically active compounds for the development of new pharmaceuticals. Its unique structure and potential medicinal properties make it a valuable component in the creation of drugs with antiviral and antitumor capabilities.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, Thiazolo[5,4-b]pyridin-2-amine is employed as a subject of study to explore its diverse reactivity and pharmacological potential. Researchers are interested in understanding how its structural features can be leveraged to develop new therapeutic agents with improved efficacy and selectivity.
Used in Drug Design and Development:
Thiazolo[5,4-b]pyridin-2-amine is used as a structural template in drug design, aiming to create novel molecules with specific therapeutic targets. Its incorporation into drug candidates can potentially enhance the pharmacokinetic and pharmacodynamic profiles of new medications, leading to more effective treatments for various diseases.

InChI:InChI=1/C6H5N3S/c7-6-9-4-2-1-3-8-5(4)10-6/h1-3H,(H2,7,9)

Upstream product

• 742640-87-5 N-thiazolo[5,4-b]pyridin-2-yl-benzamide 
• 5470-18-8 2-Chloro-3-nitropyridine 
• 17356-08-0 thiourea 
• 117087-45-3 (2-chloropyridin-3-yl)hydrazine 
• 6298-19-7 2-chloro-3-aminopyridine 
• 7647-01-0 hydrogenchloride 
• 67446-36-0 3-nitro-[2]pyridylsulfanyl cyanate 
• 7732-18-5 water 
• 117087-46-4 1-(2-chloropyridyl-3)-4-ethoxycarbonyl thiosemicarbazide 
• 333-20-0 potassium thioacyanate 

Downstream Products

• 38240-21-0 2-mercapto-3-amino pyridine 
• 865663-84-9 (6-iodo-quinazolin-4-yl)-thiazolo[5,4-b]pyridin-2-yl-amine 
• 50621-23-3 phenyl thiazolo[5,4-b]pyridin-2-ylcarbamate 
• 1280215-13-5 C₁₄H₁₂N₄OS 
• 1280215-17-9 C₁₃H₇Cl₃N₄OS 
• 1280215-18-0 C₁₃H₉BrN₄OS 
• 1280215-19-1 C₁₃H₉ClN₄OS 
• 1280215-21-5 C₁₄H₁₂N₄OS 
• 1280215-22-6 C₁₄H₁₂N₄OS 
• 1280215-28-2 C₁₃H₉N₅O₃S 
• 412923-40-1 2-bromothiazolo[5,4-b]pyridine 
• 1021164-79-3 2-(2,6-Dichlorophenyl)-1H-indole-6-carboxylic acid thiazolo[5,4-b]pyridin-2-ylamide 
• 1258527-36-4 C₃₃H₃₄FN₅O₃S 

Relevant articles and documents

Hydrazone-based derivative, intermediate, preparation method, pharmaceutical composition and applications thereof

The present invention discloses a hydrazone-based derivative (I), an intermediate, a preparation method, a pharmaceutical composition and applications thereof, wherein the hydrazone-based compound hasgood inhibitory effect on the ubiquitination activity of cIAP1 protein, can promote the degradation of oncogenic protein c-MYC at a cellular level so as to inhibit the growth of tumor cells, and hasbroad drug development prospects.

Polymerizable compound, polymerizable composition, polymer, and optically anisotropic material

The present invention relates to: a polymerizable compound (I), wherein Y1 to Y6 are a chemical single bond, —O—C(═O)—, —C(═O)—O— or the like, G1 and G2 are a divalent aliphatic group, Z1 and Z2 are an alkenyl group, Ax is a fused ring group represented by a formula (II), wherein X is —NR3—, an oxygen atom, a sulfur atom or the like, R3 is a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, and D is a substituted or unsubstituted ring having 1 to 20 carbon atoms that includes at least one nitrogen atom, Ay is a hydrogen atom, an alkyl group, A1 is a trivalent aromatic group or the like, A2 and A3 are a divalent aromatic group having 6 to 30 carbon atoms or the like, and Q1 is a hydrogen atom, or an alkyl group having 1 to 6 carbon atoms.

POLYMERIZABLE COMPOUND, POLYMERIZABLE COMPOSITION, POLYMER, OPTICALLY ANISOTROPIC BODY, AND METHOD FOR PRODUCING POLYMERIZABLE COMPOUND

A polymerizable compound has a practical low melting point, excellent solubility in a general-purpose solvent, and can produce an optical film at low cost, exhibits low reflected luminance, and achieves uniform conversion of polarized light over a wide wavelength band, an optically anisotropic article. A carbonyl compound is useful as a raw material for producing the polymerizable compound. (In the formula (I), Y1 to Y8 represent —C(═O)—O—, G1 and G2 represent a C1-20 divalent linear aliphatic group, Z1 and Z2 represent a C2-10 alkenyl group that is unsubstituted, or substituted with a halogen atom, Ax represents a C2-30 organic group with at least one aromatic ring, Ay represents a hydrogen atom or C1-20 alkyl group, A1 represents a trivalent aromatic group, A2 and A3 represent a C3-30 divalent alicyclic hydrocarbon group, A4 and A5 represent a C6-30 divalent aromatic group or the like, and Q1 represents a hydrogen atom.)

A new method for synthesizing asymmetric urea containing thiazolo[5,4-b]pyridine and applications in agriculture

Chemical Equation Presented In this article, we describe the use of diphenyl carbonate (DPC) as a carbonyl source instead of isocyanate to synthesize asymmetric substituted urea derivatives. In a study aiming to discover new lead compounds with agricultur

A single-step preparation of thiazolo[5,4-b]pyridine- and thiazolo[5,4-c]pyridine derivatives from chloronitropyridines and thioamides, or thioureas

(Chemical Equation Presented) A one-step synthesis of thiazolo[5,4-b] pyridines from an appropriately substituted chloronitropyridine and thioamide, or thiourea, is presented. In particular, the reaction was used to prepare a large number of 6-nitrothiazo

Transformations of 1-(2-Chloropyridyl-3)-4-ethoxycarbonyl- and 1-(2-Chloropyridyl-3)-4-ethoxycarbonylmethyl Thiosemicarbazides. Attempts to Prepare Pyrido-1,2,4-thiadiazine

2-Chloro-3-hydrazinopyridine (2) was converted with ethoxycarbonyl and ethoxycarbonylmethyl isothiocyanates into 1,4-disubstituted thiosemicarbazides 3 and 4, while with phenyl isothiocyanate directly 1H-pyrido-1,3,4-thiadiazine 7 was formed.Attempts to cyclize the thiosemicarbazides 3 and 4 into pyridothiadiazine derivatives 5 and 6 failed.In the reaction of 3 with hydrazine 2-aminothiazolopyridine (9) was formed, while 4 gave only the corresponding hydrazide 10.The cyclization of the side chain occured in compound 4 by heating in aqueous hydrochloric acid to give 11, which was further transformed with N,N-dimethylformamide dimethyl acetal (DMFDMA) into 12, while with diethyl acetylene dicarboxylate the thiazolidone derivative 13 was produced. - Keywords: 1,4-Disubstituted thiosemicarbazides; 1H-Pyrido-1,3,4-thiadiazines; Thiazolidones