31795-61-6

Basic information

• Product Name: 6-(HYDROXYMETHYL)NICOTINONITRILE
• Synonyms: 6-(HYDROXYMETHYL)NICOTINONITRILE;(5-Cyano-pyridin-2-yl)methanol;6-Hydroxymethylpyridine-3-carbonitrile
• CAS NO: 31795-61-6
• Molecular Formula: C₇H₆N₂O
• Molecular Weight: 134.05
• Mol File: 31795-61-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 303.144 °C at 760 mmHg
• Flash Point: 137.137 °C
• Appearance: /
• Density: 1.257 g/cm³
• Vapor Pressure: 0.000418mmHg at 25°C
• Refractive Index: 1.575
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 13.06±0.10(Predicted)
• CAS DataBase Reference: 6-(HYDROXYMETHYL)NICOTINONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(HYDROXYMETHYL)NICOTINONITRILE(31795-61-6)
• EPA Substance Registry System: 6-(HYDROXYMETHYL)NICOTINONITRILE(31795-61-6)

Safety Data

• Hazardous Substances Data: 31795-61-6(Hazardous Substances Data)

Usage

Uses

6-(Hydroxymethyl)nicotinonitrile is the derivative of 5-Cyano-2-methylpyridine (C981875), which is used to synthesize acridone-based inhibitors of inosine 5''-monophosphate dehydrogenase (IMPDH). It is also used in the preparation of potent and selective nonpeptidic inhibitors of procollagen C-proteinase.This compound is suitable for pyruvate dehydrogenase (PDH) related research.

InChI:InChI=1/C7H6N2O/c8-3-6-1-2-7(5-10)9-4-6/h1-2,4,10H,5H2

Upstream product

• 100-54-9 pyridine-3-carbonitrile 
• 67-56-1 methanol 
• 557-21-1 zinc(II) cyanide 
• 88139-91-7 (5-bromopyridin-2-yl)methanol 
• 143-33-9 sodium cyanide 
• 31795-60-5 (5-cyano-2-pyridinyl)methylacetate 

Downstream Products

• 206201-64-1 5-cyanopyridine-2-carboxaldehyde 
• 1312008-07-3 (5-cyanopyridin-2-yl)methyl methanesulfonate 
• 83640-36-2 6-(chloromethyl)nicotinonitrile 

Relevant articles and documents

BENZIMIDAZOLE DERIVATIVES AND THEIR USES

The present invention relates to inhibitors of Transient Receptor Potential Channel 6 (TRPC6) protein activity. The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising

BENZISOXAZOLE COMPOUND

Disclosed is a compound represented by the general formula (I) or a salt thereof: wherein any one of R1, R2 and R3 represents a group represented by the formula: -(CH2)m-NR11R12 (wherein m is 1 or 2; and R11 and R12 independently represent a hydrogen atom or a C1-6 alkyl group or may, together with a nitrogen atom to which R11 and R12 are bound, form a 4- or 5-membered cyclic group); the remaining two or R1, R2 and R3 independently represent a group represented by the formula: -(O)n-R21 (wherein n is 0 or 1; and R21 represents a hydrogen atom, a C1-6 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, or the like); and R4 represents a C1-6 alkyl group which may have a substituent or the like.

DIHYDROPYRIDINE DERIVATIVES FOR USE AS HUMAN NEUTROPHIL ELASTASE INHIBITORS

The invention relates to novel dihydropyridine derivatives, of Formula (I) processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.