83640-36-2

Usage

Uses

Used in Pharmaceutical Industry:
6-ChloroMethyl-nicotinonitrile is used as an intermediate in the synthesis of various drugs for its potential applications in the field of medicinal chemistry.
6-ChloroMethyl-nicotinonitrile is used as a building block for the preparation of diverse bioactive molecules, contributing to the development of new and more effective therapeutic agents for a range of medical conditions.

Upstream product

• 3222-48-8 6-methylnicotinonitrile 
• 88139-91-7 (5-bromopyridin-2-yl)methanol 
• 124-63-0 methanesulfonyl chloride 
• 31795-61-6 6-(hydroxymethyl)pyridine-3-carbonitrile 
• 694-59-7 pyridine N-oxide 
• 31795-59-2 6-methylpyridine-3-carbonitrile 1-oxide 

Downstream Products

• 150461-43-1 methyl 3-<1-(4-chlorobenzyl)-4-methyl-6-<(5-cyanopyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-c,d>indol-2-yl>-2,2-dimethylpropanoate 

Relevant academic research and scientific papers

BENZIMIDAZOLE DERIVATIVES AND THEIR USES

The present invention relates to inhibitors of Transient Receptor Potential Channel 6 (TRPC6) protein activity. The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising

AZOLE DERIVATIVES

Azole derivatives of the formulas R1-CR2R3-CHR4-CR5R6-R7 are described; wherein R1 is a heterocyclyl radicla selected from 1,2,4-triazolyl, optionally-substituted imidazolyl, pyridyl and pyrimidinyl radicals; R2 and R3, which may be the same or differen

Use of olefinic compounds

The use of an olefinic compound of the formula wherein R1 is a heterocyclyl radical selected from 1,2,4-triazolyl, imidazolyl, 5-(1-6C alkyl)imidazol-1-yl, pyridyl and pyrimidinyl; R2 and R3, which may be the same or d

Synthesis of Azaanthraquinones: Homolytic Substitution of Pyridines

Synthesis of specific di- and tri-hydroxyazaanthraquinones by Friedel-Crafts procedures is limited by orientational ambiguity and by the lack of reactivity of pyridine derivatives in electrophilic acylation processes; however, suitable pyridines have been made to undergo radical benzoylation and benzylation at unsubstituted positions 2, 4 and 6.In particular, derivatives of pyridine-3-carbonitrile have been benzoylated at positions 2 and 4.Ring closure by intramolecular Houben-Hoesch reaction has then led to specifically substituted 1- and 2-azaanthraquinones and thence to the antibiotic bostrycoidin (1).