3182-78-3Relevant academic research and scientific papers
Polymersomes with aggregation-induced emission based on amphiphilic block copolypeptoids
Tao, Xinfeng,Chen, Hui,Trépout, Sylvain,Cen, Jiayu,Ling, Jun,Li, Min-Hui
, p. 13530 - 13533 (2019)
Biocompatible polymersomes are prepared from amphiphilic block copolypeptoids with aggregation-induced emission, where the hydrophobic block P(TPE-NAG) is a tetraphenylethylene (TPE)-modified poly(N-Allylglycine) and the hydrophilic block is polysarcosine
Biomimetic Approaches Employing the Ugi Five-Center Four-Component Reaction for Synthesis of the Right-Hand Portion of Halichonadin Q and the Central Part of Halichonadin M
Mimura, Rika,Kitamori, Ayumi,Ikeda, Akifumi,Masuda, Toshiya,Nakano, Keiji,Kotsuki, Hiyoshizo,Ichikawa, Yoshiyasu
, p. 3043 - 3048 (2015)
One-pot syntheses of models of the right-hand portion and the central part of the respective structures of halichonadins Q and M, using the Ugi five-center four-component reaction (U-5C-4CR), were executed. The biomimetic strategy employed in these routes demonstrates the feasibility of pathways we have proposed for the biosynthesis of marine organisms.
Charge-Determined LCST/UCST Behavior in Ionic Polypeptoids
Xing, Chao,Shi, Zhekun,Tian, Jiliang,Sun, Jing,Li, Zhibo
, p. 2109 - 2116 (2018)
Stimuli-responsive polymers have received increasing interest for a variety of applications. Here, we report a series of unique charge-determined thermoresponsive polypeptoids synthesized by a combination of ring-opening polymerization and click chemistry. The LCST-type and UCST-type behavior is mainly dominated by the charge state on the side chain. Further, the phase transition temperature highly depends on the degree of polymerization, the side-chain architecture, the pH value, and so on. The obtained polypeptoid solutions exhibit good stability against temperature and salt concentration. To our knowledge, this report presents the first charge-determined LCST/UCST-type polymer from identical homopolymer backbone that displays a wide range of tunable cloudy points in aqueous media. We propose the hydrogen-bonding interaction plays a critical part on the solution behavior. These features make polypeptoids ideal candidates for highly designable stimuli-responsive polymeric materials.
Homopolymer electrolyte composite vesicle, preparation method thereof, antibacterial vesicle, vesicle entrapped with hydrophobic substance and anti-adhesion vesicle
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Paragraph 0149-0152, (2021/10/11)
The invention relates to the technical field of bio-macromolecules, and provides a homopolymer electrolyte composite vesicle, a preparation method thereof, an antibacterial vesicle, a vesicle entrapped with hydrophobic substance and an anti-adhesion vesicle. According to the invention, two kinds of polypeptoides with opposite charges are self-assembled into the stable nano-scale homopolymer electrolyte composite vesicle through the electrostatic interaction, the vesicles have the good membrane permeation characteristic, have the good sterilization effect under the acid condition and can entrap hydrophobic substances, the surface of the vesicles has the characteristics of zwitter-ions, and has good protein adhesion resistance. The antibacterial vesicle provided by the invention has excellent sterilization capability, and especially has strong sterilization capability on gram-positive bacteria; the vesicles entrapped with the hydrophobic substances can entrap various hydrophobic dyes or drugs, and efficient delivery of the drugs is achieved; furthermore, the vesicles are more stable after being lightly cross-linked on the surface, the adhesion resistance is better, and the release rate of internal drugs can be effectively regulated and controlled.
A mild and efficient method for the one-pot monocarboxymethylation of primary amines
Gibbs, Timothy J. K.,Boomhoff, Michael,Tomkinson, Nicholas C. O.
, p. 1573 - 1576 (2008/02/04)
A mild and efficient method for the monocarboxymethylation of primary amines that takes place under aqueous conditions at room temperature is described. Treatment of an aqueous solution of a variety of primary amines with two equivalents of glyoxylic acid
