318233-98-6

Basic information

• Product Name: 1H-Pyrazole-4-carboxaldehyde, 1-methyl-5-[(4-methylphenyl)thio]-3-phenyl-
• CAS NO: 318233-98-6
• Molecular Formula: C18H16N2OS
• Molecular Weight: 308.404
• Mol File: 318233-98-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1H-Pyrazole-4-carboxaldehyde, 1-methyl-5-[(4-methylphenyl)thio]-3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-4-carboxaldehyde, 1-methyl-5-[(4-methylphenyl)thio]-3-phenyl-(318233-98-6)
• EPA Substance Registry System: 1H-Pyrazole-4-carboxaldehyde, 1-methyl-5-[(4-methylphenyl)thio]-3-phenyl-(318233-98-6)

Safety Data

• Hazardous Substances Data: 318233-98-6(Hazardous Substances Data)

Upstream product

• 883-38-5 5-chloro-1-methyl-3-phenyl-1H-pyrazole-4-carboxaldehyde 
• 106-45-6 para-thiocresol 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 34347-81-4 1-methyl-3-phenyl-5-hydroxyl-1H-pyrazol 

Relevant articles and documents

5-((1H-Pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one inhibitors of ADAMTS-5

A series of 5-((1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one inhibitors of ADAMTS-5 (aggrecanase-2) is described. These compounds show μM functional inhibition of ADAMTS-5, and represent a new class of agents with the potential of inhibiting degradation of aggrecan, a major component of cartilage which is lost in osteoporosis. Compound 12 is noteworthy in that it has an ADAMTS-5 IC50: 1.1 μM and shows >40-fold functional selectivity over ADAMTS-4 (aggrecanase-1).