3185-97-5Relevant academic research and scientific papers
Quinoxaline-phosphonic acid derivatives
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, (2008/06/13)
The disclosure relates to quinoxaline derivatives of Formula I wherein R1, R4, R5, R6, R7 and R8 are as defined in the disclosure, as well as their production and use in medicinal agents.
Pyrrolylquinoxalinediones: A new class of AMPA receptor antagonists
Lubisch,Behl,Hofmann
, p. 2887 - 2892 (2007/10/03)
Pyrrolylquinoxalinediones were synthesized and their affinities for the AMPA receptor were determined. Most compounds showed moderate to good affinities. The acetic acid derivative 8b exhibited a K(i) value of 70 nM and was equipotent to NBQX 1. Structure activity relationships are discussed. Selected compounds were tested for their potency to inhibit AMPA induced lethal convulsions in mice. In this in vivo model the compounds showed improved potency compared with NBQX.
Direct Cleavage of Peptides from a Solid Support into Aqueous Buffer. Application in Simultaneous Multiple Peptide Synthesis
Bray, Andrew M.,Maeji, N. Joe,Valerio, Robert M.,Campbell, Rhonda A.,Geysen, H. Mario
, p. 6659 - 6666 (2007/10/02)
A method of simultaneous multiple peptide synthesis which integrates synthesis, side-chain deprotection, cleavage, and purification so as to afford peptide solutions suitable for immediate biological testing is described.The approach utilizes a novel dike
