3189-48-8

Basic information

• Product Name: INDOLIZINE-2-CARBOXYLIC ACID
• Synonyms: INDOLIZINE-2-CARBOXYLIC ACID
• CAS NO: 3189-48-8
• Molecular Formula: C₉H₇NO₂
• Molecular Weight: 161.16
• Mol File: 3189-48-8.mol
• Article Data: 12

Chemical Properties

• Melting Point: 240-241 °C (decomp)
• Appearance: /
• Density: 1.28g/cm³
• Refractive Index: 1.627
• Storage Temp.: 2-8°C
• PKA: 1.60±0.41(Predicted)
• CAS DataBase Reference: INDOLIZINE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: INDOLIZINE-2-CARBOXYLIC ACID(3189-48-8)
• EPA Substance Registry System: INDOLIZINE-2-CARBOXYLIC ACID(3189-48-8)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-28-37/39
• Hazardous Substances Data: 3189-48-8(Hazardous Substances Data)

Usage

Uses

Indolizine-2-carboxylic Acid is used to prepare acylaminophenyloxazoles as inosine monophosphate dehydrogenase inhibitors. It is also used to synthesize indolizine-2-carboxamides as potential HIV-1 protease inhibitors.

InChI:InChI=1/C9H7NO2/c11-9(12)7-5-8-3-1-2-4-10(8)6-7/h1-6H,(H,11,12)

Upstream product

• 131211-78-4 methyl 2-[acetoxy(pyridin-2-yl)methyl]acrylate 
• 1121-60-4 pyridine-2-carbaldehyde 
• 118488-74-7 2-(hydroxy-pyridin-2-yl-methyl)-acrylic acid methyl ester 
• 16959-62-9 methyl indolizine-2-carboxylate 
• 4491-43-4 1,2,3-Indolizintricarbonsaeure-trimethylester 
• 109-06-8 α-picoline 
• 70-23-5 ethyl Bromopyruvate 

Downstream Products

• 13618-93-4 indolizidine 
• 1236277-12-5 N-[2-(benzylthio)ethyl]indolizine-2-carboxamide 
• 525-42-8 1,3-bisacetylindolizine 
• 16959-62-9 methyl indolizine-2-carboxylate 
• 16959-59-4 5,6,7,8-tetrahydroindolizine-2-carboxylic acid 

Relevant articles and documents

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Propylphosphonic acid anhydride–mediated amidation of Morita–Baylis–Hillman–derived indolizine-2-carboxylic acids

Propylphosphonic acid anhydride has been successfully used as a coupling agent in the synthesis of a series of indolizine-2-carboxamido derivatives from indolizine-2-carboxylic acid and its 3-acetylated analogue. The acid substrates were obtained by sapon

NOVEL INDOLIZINE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)

The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.