INDOLIZINE-2-CARBOXYLIC ACID

Base Information

• Chemical Name: INDOLIZINE-2-CARBOXYLIC ACID
• CAS No.: 3189-48-8
• Molecular Formula: C9H7NO2
• Molecular Weight: 161.16
• Hs Code.: 2933990090
• Mol file: 3189-48-8.mol

Synonyms:Pyrrolcolin-carbonsaeure-(2);Indolizin-carbonsaeure-(2);Indolizin-carbonsaeure-(1);Indolizin-2-carbonsaeure;2-Indolizine,carboxylic acid;

Chemical Property of INDOLIZINE-2-CARBOXYLIC ACID

Chemical Property:

• Melting Point: 240-241 °C (decomp)
• PKA: 1.60±0.41(Predicted)
• PSA: 41.71000
• Density: 1.28g/cm3
• LogP: 1.63750
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Indolizine-2-carboxylic Acid ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-28-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Indolizine-2-carboxylic Acid is used to prepare acylaminophenyloxazoles as inosine monophosphate dehydrogenase inhibitors. It is also used to synthesize indolizine-2-carboxamides as potential HIV-1 protease inhibitors.

Technology Process of INDOLIZINE-2-CARBOXYLIC ACID

There total 7 articles about INDOLIZINE-2-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl indolizine-2-carboxylate (16959-62-9) → indolizine-2-carboxylic acid (3189-48-8)

Guidance literature:

With potassium hydroxide; In ethanol; for 16h; Heating;

Reference yield:

pyridine-2-carbaldehyde (1121-60-4) → indolizine-2-carboxylic acid (3189-48-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1,4-diaza-bicyclo[2.2.2]octane / 5 h / 0 °C

2: methanol / 1.67 h / 100 °C / Microwave irradiation

3: potassium hydroxide / ethanol / 16 h / 100 °C

With 1,4-diaza-bicyclo[2.2.2]octane; potassium hydroxide; In methanol; ethanol; 1: |Morita-Baylis-Hillman Alkylation;

DOI:10.5935/0103-5053.20130056

Reference yield:

2-(hydroxy-pyridin-2-yl-methyl)-acrylic acid methyl ester (118488-74-7) → indolizine-2-carboxylic acid (3189-48-8)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 1.67 h / 100 °C / Microwave irradiation

2: potassium hydroxide / ethanol / 16 h / 100 °C

With potassium hydroxide; In methanol; ethanol;

DOI:10.5935/0103-5053.20130056

upstream raw materials:

α-picoline

ethyl Bromopyruvate

1,2,3-Indolizintricarbonsaeure-trimethylester

methyl indolizine-2-carboxylate