318972-70-2Relevant academic research and scientific papers
N,N′-bis-(2-(cyano)ethoxycarbonyl)-2-methyl-2-thiopseudourea: A guanylating reagent for synthesis of 2′-O-[2-(guanidinium)ethyl]-modified oligonucleotides
Prakash, Thazha P.,Pueschl, Ask,Manoharan, Muthiah
, p. 149 - 159 (2007)
A guanylating reagent, N,N′-bis-(2-(cyano)ethoxycarbonyl)-2- thiopseudourea, was synthesized and used for synthesis of 2′-O-[2- (guanidinium)ethyl] (2′-O-GE) modified oligonucleotides. A convenient deprotection method for the 2′-O-GE oligonucleotides was
2′-O-[2-(Guanidinium)ethyl]-modified oligonucleotides: Stabilizing effect on duplex and triplex structures
Prakash, Thazha P.,Pueschl, Ask,Lesnik, Elena,Mohan, Venkatraman,Tereshko, Valentina,Egli, Martin,Manoharan, Muthiah
, p. 1971 - 1974 (2007/10/03)
Equation presented. Oligonucleotides with a novel 2′-O-[2- (guanidinium)ethyl] (2′-O-GE) modification have been synthesized using a novel protecting group strategy for the guanidinium group. This modification enhances the binding affinity of oligonucleoti
