242147-79-1

Upstream product

• 242147-78-0 2'-O-(2-phthalimidoethyl)-5'-O-(4,4'-dimethoxytrityl)-5-methyluridine 
• 302-01-2 hydrazine 
• 1263796-39-9 C₃₃H₃₅N₅O₈ 
• 1263796-38-8 C₃₄H₃₈N₂O₁₁S 
• 212061-57-9 2'-O-(2-Hydroxyethyl)-5'-O-dimethoxytrityl-5-methyluridine 
• 817623-11-3 2,2'-anhydro-1-[2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl-5-methyluridine] 
• 1463-10-1 5-Methyluridine 
• 22423-26-3 O-2,2'-cyclo-5-methyluridine 

Downstream Products

• 318972-70-2 2'-O-[2-(N',N''-bis(2-cyano)ethoxycarbonyl)-guanidino)ethyl]-5'-O-(4,4'-dimethoxytrityl)-5-methyl uridine 
• 1412707-61-9 2'-O-{2-[3-(7,8-didehydro-1,2:5,6-dibenzocyclooctynyl)oxyamido]ethyl}-5'-O-(4,4'-dimethoxytrityl)-5-methyluridine 
• 242147-80-4 2'-O-[N-(2-cyanoethoxycarbonyl)-2-aminoethyl]-5'-O-(4,4'-dimethoxytrityl)-5-methyluridine 

Relevant academic research and scientific papers

OLIGONUCLEOTIDE LIGATION

A method for joining oligonucleotides. The method includes joining together one or more oligonucleotides by reacting an alkyne group lined to an oligonucleotide with an azide group linked to an oligonucleotide to form a triazole linkage. The alkyne group is a strained alkyne group. The method can include ligating together ends of one or more oligonucleotides or cross-linking strands of an oligonucleotide duplex. The methods described allow oligonucleotide strands to be ligated together without the need for a ligase enzyme.

Guanidinium functionalized oligonucleotides and method/synthesis

The present invention provides oligomers which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the nucleoside moieties of the oligomer is modified to include a guanidinium group. These oligomers are useful for diagnostic, therapeutic and investigative purposes.

Methods for the preparation of conjugated oligomers

The present invention provides novel methods for preparing oligonucleotide conjugates using a novel electrophilic haloacetyl linker. Novel compounds and intermediates are also disclosed.