Uridine, 2'-O-[2-[[bis[[(2-cyanoethoxy)carbonyl]amino]methylene]amino]ethyl]-5'- O-[bis(4-methoxyphenyl)phenylmethyl]-5-methyl-

Base Information

• Chemical Name: Uridine, 2'-O-[2-[[bis[[(2-cyanoethoxy)carbonyl]amino]methylene]amino]ethyl]-5'- O-[bis(4-methoxyphenyl)phenylmethyl]-5-methyl-
• CAS No.: 318972-70-2
• Molecular Formula: C42H45N7O12
• Molecular Weight: 839.859
• Mol file: 318972-70-2.mol

Synonyms:

Chemical Property of Uridine, 2'-O-[2-[[bis[[(2-cyanoethoxy)carbonyl]amino]methylene]amino]ethyl]-5'- O-[bis(4-methoxyphenyl)phenylmethyl]-5-methyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Uridine, 2'-O-[2-[[bis[[(2-cyanoethoxy)carbonyl]amino]methylene]amino]ethyl]-5'- O-[bis(4-methoxyphenyl)phenylmethyl]-5-methyl-

There total 1 articles about Uridine, 2'-O-[2-[[bis[[(2-cyanoethoxy)carbonyl]amino]methylene]amino]ethyl]-5'- O-[bis(4-methoxyphenyl)phenylmethyl]-5-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

2'-O-[2-(amino)ethyl]-5'-O-(4,4'-dimethoxytrityl)-5-methyluridine (242147-79-1) + [[[(2-cyanoethoxy)carbonyl]amino](methylthio)methylene]carbamic acid 2-cyanoethyl ester (318972-65-5) → 2'-O-[2-(N',N''-bis(2-cyano)ethoxycarbonyl)-guanidino)ethyl]-5'-O-(4,4'-dimethoxytrityl)-5-methyl uridine (318972-70-2)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield: 64.0%

N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite (102691-36-1) + 2'-O-[2-(N',N''-bis(2-cyano)ethoxycarbonyl)-guanidino)ethyl]-5'-O-(4,4'-dimethoxytrityl)-5-methyl uridine (318972-70-2) → 2'-O-[2-(N',N''-bis(2-(cyano)ethoxycarbonyl)-guanidino)ethyl]-5'-O-(4,4'-dimethoxytrityl)-5-methyluridine-3'-[(2-cyanoethyl)-N,N-diisopropyl]phosphoramidite

Guidance literature:

With N,N-diisopropylamine tetrazolide; In acetonitrile; at 20 ℃; for 5h;

DOI:10.1080/15257770601112705

Reference yield:

succinic acid anhydride (108-30-5) + 2'-O-[2-(N',N''-bis(2-cyano)ethoxycarbonyl)-guanidino)ethyl]-5'-O-(4,4'-dimethoxytrityl)-5-methyl uridine (318972-70-2) → C46H49N7O15

Guidance literature:

With pyridine; dmap; In dichloromethane; at 20 ℃;

upstream raw materials:

2'-O-[2-(amino)ethyl]-5'-O-(4,4'-dimethoxytrityl)-5-methyluridine

[[[(2-cyanoethoxy)carbonyl]amino](methylthio)methylene]carbamic acid 2-cyanoethyl ester