318988-50-0

Upstream product

• 645-36-3 2,2-diethoxy-ethanamine 
• 105-36-2 ethyl bromoacetate 
• 501-53-1 benzyl chloroformate 
• 74141-19-8 ethyl 2-[(2,2-diethoxyethyl)amino]acetate 

Downstream Products

• 434930-41-3 N-benzyloxycarbonyl-N-(2,2-diethoxyethyl)aminoacetic acid fluoride 
• 441790-58-5 tetrahydro-5-oxo-1'-(phenylmethyl)spiro[imidazo[1,2-a]pyrazine-2(3H),4'-piperidine]-7(1H)-carboxylic acid phenylmethyl ester 
• 318988-53-3 tetrahydro-5-oxo-1'-(phenylmethyl)spiro[7H-oxazolo[3,2-a]pyrazine-2(3H),4'-piperidine]-7-carboxylic acid phenylmethyl ester 
• 441790-62-1 tetrahydro-1-methyl-5-oxo-1'-(4-pyridinyl)spiro[imidazo[1,2-a]pyrazine-2(3H),4'-piperidine]-7(1H)-carboxylic acid phenylmethyl ester 
• 441790-60-9 tetrahydro-5-oxo-1'-(4-pyridinyl)spiro[imidazo[1,2-a]pyrazine-2(3H),4'-piperidine]-7(1H)-carboxylic acid phenylmethyl ester 
• 318988-55-5 tetrahydro-5-oxo-1'-(4-pyridinyl)spiro[7H-oxazolo[3,2-a]pyrazine-2(3H),4'-piperidine]-7-carboxylic acid phenylmethyl ester 
• 441790-59-6 C₁₈H₂₄N₄O₃ 
• 318988-54-4 1,4-diaza-4-(benzyloxycarbonyl)-7-oxaspiro[bicyclo[4.3.0]nonane-8,4'-piperidin]-2-one 
• 318988-51-1 N-(2-oxoethyl)-N-[(phenylmethoxy)carbonyl]glycine ethyl ester 
• 239074-33-0 N-benzyloxycarbonyl-N-(2,2-diethoxyethyl)-glycine 

Relevant academic research and scientific papers

Synthesis and evaluation of 1-arylsulfonyl-3-piperazinone derivatives as factor Xa inhibitors1-4 V. A series of new derivatives containing a spiro[imidazo[1,2-a]pyrazine-2(3H),4′-piperidin]-5(1H)-one scaffold

We have already reported unique compounds containing a N,O-spiro acetal structure as an orally active factor Xa (FXa) inhibitor. This time, we described a N,N-spiro acetal structure as an analogue of the N,O-spiro acetal structure for an orally active FXa

TRICYCLIC COMPOUND HAVING SPIRO UNION

This invention relates to tricyclic compounds having spiro union represented by the following formula (I) or its salt which is useful as a drug, and in particular, as an inhibitor for activated blood coagulation factor X, which can be administered orally and which exhibits strong anticoagulation action. The invention also relates to a pharmacophore which was derived from the compound and is useful in molecular designing of the FXa inhibitor.

TRICYCLIC COMPOUNDS HAVING SPIRO UNION

This invention relates to tricyclic compounds having spiro union represented by the following formula (I) or its salt which is useful as a drug, and in particular, as an inhibitor for activated blood coagulation factor X, which can be administered orally

Synthesis of optically active C-allylglycine derivatives and conversion into isoquinolones

C-Allylglycyl amides can be efficiently synthesized via an auxiliary controlled diastereoselective aza-Claisen rearrangement. The stereodirecting unit is placed on an auxiliary derived from commercially available (S)-proline. After N-allylation, the obtained optically active allylamines were reacted with various N-protected glycyl fluorides to give the (2R)-C-allylglycyl amides in good yields. The diastereoselectivity of the asymmetric allylation varied between 1:1 and > 1:15 depending on the N-protective group, the auxiliary, and the reaction temperature. Likewise, the C-allylglycine derivatives can be used as monomers in peptide synthesis to synthesize (R)-proline derivatives or chiral isoquinolones; the latter should serve as building blocks in the total syntheses of alkaloids.