319-92-6

Usage

Uses

Used in Pharmaceutical Industry:
2,3,5,6-TetraMethylfluorobenzene is used as a solvent in the manufacturing of pharmaceuticals, aiding in the production process of various medicinal compounds.
Used in Pesticide Industry:
In the pesticide industry, 2,3,5,6-TetraMethylfluorobenzene serves as a solvent, contributing to the formulation of effective pest control products.
Used in Organic Compounds Synthesis:
2,3,5,6-TetraMethylfluorobenzene is used as a raw material in the synthesis of specialty chemicals, highlighting its versatility as a chemical intermediate.
Used in Dye and Pigment Production:
2,3,5,6-TetraMethylfluorobenzene is utilized in the production of dyes and pigments, playing a crucial role in the coloration of various products.
Used in Flavor and Fragrance Industry:
2,3,5,6-TetraMethylfluorobenzene is used as a flavor and fragrance ingredient, adding to the sensory characteristics of food, beverages, and perfumes.
Used in Cosmetics Manufacturing:
As an additive in the manufacturing of cosmetics, 2,3,5,6-TetraMethylfluorobenzene contributes to the formulation of various cosmetic products, enhancing their performance and appeal.
It is important to handle 2,3,5,6-TetraMethylfluorobenzene with care, as it may pose health risks if ingested, inhaled, or comes into contact with the skin or eyes.

Upstream product

• 2925-03-3 p-Aminofluorodurene 
• 95-93-2 1,2,4,5-tetramethylbenzene 
• 76-05-1 trifluoroacetic acid 
• 711-45-5 p-Fluoronitrodurene 

Relevant academic research and scientific papers

Fluorination of aromatic compounds with N-fluorobenzenesulfonimide under solvent-free conditions

Reactions of N-fluorobenzenesulfonimide with methylbenzenes, phenols, and phenol ethers were studied under solvent-free conditions. The rate constant ratio for the reactions with mesitylene and durene indicates polar mechanism of the process. Solvent-free fluorination of aromatic compounds with N-fluorobenzenesulfonimide in some cases is more selective than reactions with other N-F reagents in a solvent.

First application of ionic liquids in electrophilic fluorination of arenes; Selectfluor (F-TEDA-BF4) for "green" fluorination

The NF fluorinating agent F-TEDA-BF4 dication salt (Selectfluor) 1 dissolves in imidazolium-based ionic liquids [emim][OTf] 7, [emim][BF4] 8, [bmim][PF6] 9 and [bmim][BF4] 10 (assisted by sonication), providing a convenient medium for fluorination of arenes under essentially acid-free conditions in a simple set-up (no volatile solvent; simple extraction of the aromatics without aqueous work-up), from which the ionic liquid can be easily recycled and reused. Comparative studies in [emim][OTf] 7 with anisole as substrate show that 1 is superior to NFTh-BF4 (Accufluor) 2 and that the N-fluoropyridinium salt NFPy-B2F7 4 is least effective. The scope of the reaction has been surveyed. Substrate selectivity (k mesitylene: k durene = 10) measured in competitive experiments in 7 is clearly indicative of a conventional polar mechanism. Substrate selectivity measured without the ionic liquid in MeCN solvent is also indicative of a polar mechanism but exhibits lower magnitude (k mesitylene: kdurene = 6). Addition of dicyclohexano-24-crown-8 to the fluorination reaction mixture (1 and anisole) in 7 reduced the conversion but did not change the isomer distribution. AM1 minimization was used to model the complexation of 1 with this crown. With reactive aromatics optimal fluorination yields in ionic liquids (using 1 equivalent of the NF reagent) are around 50% (higher for naphthalene). A key control experiment suggests that the free base (produced upon transfer-fluorination) could complex to unreacted 1 (generating a bulky dimer complex which may be ineffective for fluorine transfer) in competition to N-protonation.

Time-resolved Spectroscopy and Charge-transfer Photochemistry of Aromatic EDA Complexes with X-Pyridinium Cations

Direct photoexcitation of 1: 1 aromatic EDA complexes with various N-substituted X-pyridinium cations (X = nitro, fluoro, methoxy and acetoxy) is achieved by the specific irradiation of their charge-transfer (CT) absorption bands.Time-resolved picosecond spectroscopy refers to charge-transfer activation by the identification of the aromatic cation radical as the initial transient (T1) formed in a photoinduced electron-transfer together with the X-pyridinyl radical.The homolytic fragmentation of the latter varies with the X-substituent in the order X = NO2 > F > AcO >CH3O, and the addition of X. to the aromatic donors leads to a series of cyclohexadienyl adducts that are identified as longer-lived transients (T2) by time-resolved (nanosecond/microsecond) spectroscopy.The phototransients T1 and T2 together account for the different types of aromatic product (resulting from ring substitution, side-chain substitution and dimerization) that are generated by steady-state CT photochemistry of the aromatic EDA complexes with X-pyridinium cations.

Effect of Catalyst on the Fluorination of Methyl-Substituted Benzenes with Xenon Difluoride

The course of acid-catalyzed liquid-phase fluorination of methyl-substituted benzene derivatives with xenon difluoride depends strongly on the structure and concentration of the substrate, its molar ratio to xenon difuoride, and the catalyst.HF-catalyzed