319427-01-5Relevant academic research and scientific papers
Alkyl ether modified polycyclic compounds having a terminal phenol and uses for protection of cells
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, (2008/06/13)
Methods and compositions are provided for achieving a cytoprotective effect by selecting a polycyclic compound with a phenol group at one end of the molecule and a carbon ring at the other such that an alkyl ether functional group in which the alkyl group has a formula CnH2n+1 (where n is at least 3 and less than 20) is positioned on the carbon ring. The compound may be used to achieve a cytoprotective effect in cells and to retard the development of a degenerative condition in a subject suffering from a disease, trauma or aging.
Synthesis and biological evaluation of 17β-alkoxyestra-1,3,5(10)-trienes as potential neuroprotectants against oxidative stress
Prokai,Oon,Prokai-Tatrai,Abboud,Simpkins
, p. 110 - 114 (2007/10/03)
17β-O-Alkyl ethers (methyl, ethyl, propyl, butyl, hexyl, and octyl) of estradiol were obtained from 3-O-benzyl-17β-estradiol with sodium hydride/alkyl halide, followed by the removal of the O-benzyl protecting group via catalytic transfer hydrogenation. A
