319452-19-2

Usage

Usage

Intermediate in the synthesis of various pharmaceuticals and agrochemicals

Known for

Potent biological activity, used as a building block in the development of new drugs

Safety

Should be handled with care and in accordance with proper safety protocols to avoid health risks

Upstream product

• 619-08-9 2-chloro-4-nitrophenol 
• 141-78-6 ethyl acetate 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 1972-28-7 diethylazodicarboxylate 

Downstream Products

• 470476-90-5 3-chloro-4-(1-methylpiperidin-4-yloxy)nitrobenzene 
• 337519-87-6 4-[1-(t-butoxycarbonyl)piperidin-4-yloxy]-3-chloroaniline 
• 925920-81-6 3-chloro-4-(piperidin-4-yloxy)nitrobenzene trifluoroacetate 
• 319452-03-4 tert-butyl 4-[2-chloro-4-nitro-5-(trimethylsilylmethyl)phenoxy]piperidine-1-caroxylate 
• 319452-01-2 tert-butyl 4-[2-chloro-4-nitro-3-(trimethylsilylmethyl)phenoxy]piperidine-1-caroxylate 
• 470476-94-9 3-chloro-4-(piperidin-4-yloxy)nitrobenzene 

Relevant academic research and scientific papers

BISARYLUREA DERIVATIVES

The present invention relates to bisarylurea derivatives of formula (I), the use of the compounds of formula (I) as inhibitors of raf-kinase, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.

BENZAMIDINE DERIVATIVES

Benzamidine derivatives of formula (I) or pharmaceutically acceptable salts thereof exhibit excellent inhibitory activity against factor Xa and are useful for treating or preventing blood coagulation disorders: wherein R 1represents a hydrogen atom, a halogen atom, an alkyl group or a hydroxyl group; R 2represents a hydrogen atom, a halogen atom or an alkyl group, R 3represents a hydrogen atom, an optionally substituted alkyl group, an aralkyl group, an optionally substituted alkanoyl group or an optionally substituted alkylsulfonyl group, R 4and R 5 are the same as or different from each other and each represent a hydrogen atom, a halogen atom, an optionally substituted alkyl group, an alkoxy group, a carboxyl group, an alkoxycarbonyl group or an optionally substituted carbamoyl group, and R 6represents a substituted pyrrolidine group or substituted piperidine group.