3195-01-5Relevant academic research and scientific papers
Total Synthesis of (S, S)-Tetramethylmagnolamine via Aerobic Desymmetrization
Huang, Zheng,Ji, Xiang,Lumb, Jean-Philip
supporting information, p. 9194 - 9197 (2019/11/14)
We describe a concise synthesis of the pseudodimeric tetrahydroisoqunoline alkaloid (S,S)-tetramethylmagnolamine by a catalytic aerobic desymmetrization of phenols. Desymmetrization reactions increase molecular complexity with high levels of efficiency, b
Enantioselective synthesis of the tetrahydrobenzyl-isoquinoline alkaloid (-)-norarmepavine using polymer supported reagents
Baxendale, Ian R.,Davidson, Thomas D.,Ley, Steven V.,Perni, Remedios H.
, p. 2707 - 2715 (2007/10/03)
We describe, in full, the enantioselective synthesis of the tetrahydrobenzylisoquinoline alkaloid (-)-norarmepavine (1) in 77% e.e. This compound was prepared using solid-supported reagents and scavengers in multi-step sequences of reactions to give mater
Asymmetric synthesis of 1-benzyltetrahydroisoquinolines using chiral oxazolo[2,3-a]tetrahydroisoquinolines
Hashigaki,Kan,Qais,Takeuchi,Yamato
, p. 1126 - 1131 (2007/10/02)
A novel synthetic route to enantiomerically pure 1-benzyltetrahydroisoquinolines (1) was developed via the reaction of oxazolo[2,3-a]tetrahydroisoquinoline (5) with benzyltriisopropoxytitanium compounds (10). This method was applied to the synthesis of (S)-trimetoquinol (1c; a bronchodilator).
