319918-15-5

Usage

Uses

Used in Organic Synthesis:
2-(Allyloxy)benzyl bromide is used as a reagent for the introduction of the benzyl bromide functional group in organic synthesis. Its ability to easily introduce this functional group makes it a valuable tool in the creation of a wide range of organic compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-(Allyloxy)benzyl bromide is used as a key intermediate in the preparation of various pharmaceutical compounds. Its unique structure and reactivity contribute to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
Similarly, in the agrochemical industry, 2-(Allyloxy)benzyl bromide serves as an important intermediate for the synthesis of agrochemicals. Its role in creating effective and targeted agrochemicals is vital for agricultural productivity and pest control.
Used in Specialty Chemicals Manufacturing:
2-(Allyloxy)benzyl bromide is also utilized in the manufacturing of specialty chemicals, where its unique properties allow for the production of high-quality and specialized chemical products for various industries.

Upstream product

• 26906-01-4 2-allyloxybenzyl alcohol 
• 90-01-7 salicylic alcohol 
• 28752-82-1 2-(allyloxy)benzaldehyde 

Downstream Products

• 1126-20-1 2-allyloxyphenol 
• 1314234-84-8 1-[(3,3-dimethylcycloprop-1-en-1-yl)methyl]-2-(prop-2-en-1-yloxy)benzene 
• 319917-52-7 (R)-1-[(3aR,5R,6S,6aR)-6-(2-Allyloxy-benzyloxy)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl]-ethane-1,2-diol 
• 319918-06-4 (R)-1-[(3aR,5R,6R,6aR)-6-(2-Allyloxy-benzyloxy)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl]-ethane-1,2-diol 
• 319917-62-9 (3aR,5R,6S,6aR)-6-(2-Allyloxy-benzyloxy)-2,2-dimethyl-5-(2-nitro-ethyl)-tetrahydro-furo[2,3-d][1,3]dioxole 

Relevant academic research and scientific papers

Tetrahydrobenzochromene Synthesis Enabled by a Deconjugative Alkylation/Tsuji-Saegusa-Ito Oxidation on Knoevenagel Adducts

A modular and practical route to versatile cyano-1,3-dienes by a sequence involving deconjugative alkylation and "Tsuji-Saegusa-Ito oxidation" is reported. In this letter, the versatility of the products is also explored, including a route to benzochromene scaffolds common to many natural products.

Novel Hypoxia-Inducible Factor 1α (HIF-1α) Inhibitors for Angiogenesis-Related Ocular Diseases: Discovery of a Novel Scaffold via Ring-Truncation Strategy

Ocular diseases featuring pathologic neovascularization are the leading cause of blindness, and anti-VEGF agents have been conventionally used to treat these diseases. Recently, regulating factors upstream of VEGF, such as HIF-1α, have emerged as a desirable therapeutic approach because the use of anti-VEGF agents is currently being reconsidered due to the VEGF action as a trophic factor. Here, we report a novel scaffold discovered through the complete structure-activity relationship of ring-truncated deguelin analogs in HIF-1α inhibition. Interestingly, analog 6i possessing a 2-fluorobenzene moiety instead of a dimethoxybenzene moiety exhibited excellent HIF-1α inhibitory activity, with an IC50 value of 100 nM. In particular, the further ring-truncated analog 34f, which showed enhanced HIF-1α inhibitory activity compared to analog 2 previously reported by us, inhibited in vitro angiogenesis and effectively suppressed hypoxia-mediated retinal neovascularization. Importantly, the heteroatom-substituted benzene ring as a key structural feature of analog 34f was identified as a novel scaffold for HIF-1α inhibitors that can be used in lieu of a chromene ring.

Rhodium-catalyzed cycloisomerization involving cyclopropenes: Efficient stereoselective synthesis of medium-sized heterocyclic scaffolds

A happy medium: The title reaction of cyclopropenyl carbinols and carbinylamines gives carbo- and heterocycles with a [6.1.0] bicyclic ring fused to an aromatic ring (see scheme, Alloc=allyloxycarbonyl, Boc=tert- butyloxycarbonyl). These reactions are the first examples of the formation of medium-sized rings by the intramolecular cyclopropanation of an alkene with a donor-substituted rhodium carbenoid, which is not generated from a diazo compound.

Direct halogenation of alcohols and their derivatives with tert-Butyl halides in the ionic liquid [pmIm]Br under sonication conditions - A novel, efficient and green methodology

A novel halogenating reagent system for direct halogenation of alcohols has been developed. tert-Butyl bromide, chloride and iodide in combination with the ionic liquid [pmIm]Br have been found to convert alcohols into the corresponding bromides, chlorides and iodides under sonication conditions (or heating) in good yields. Although a variety of primary and secondary alcohols participated in this reaction without any difficulty, tertiary alcohols remained inert. Several alcohol derivatives such as OTMS, OTBDMS, OAc, OTS and OTHP are also transformed into the corresponding halides in one-pot fashion by this procedure. A plausible rationale for this transformation is also presented. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005.