320-21-8

Usage

Uses

Used in Pharmaceutical Industry:
2,4-Bis(trifluoroMethyl)-6-nitroaniline serves as a crucial building block in the synthesis of various pharmaceuticals. Its unique structure contributes to the development of new drugs with specific therapeutic properties, making it valuable for medicinal chemistry and drug discovery.
Used in Agrochemical Industry:
In the agrochemical sector, 2,4-Bis(trifluoroMethyl)-6-nitroaniline is utilized as a key intermediate in the production of pesticides and other agrochemicals. Its incorporation into these products can enhance their effectiveness in protecting crops and controlling pests.
Used in Dye Industry:
2,4-Bis(trifluoroMethyl)-6-nitroaniline also finds application in the dye industry, where it is used as a raw material for synthesizing a range of dyes. The presence of the trifluoromethyl and nitro groups provides distinct color characteristics, which are exploited in the creation of various dye products.
Used in Chemical Product Manufacturing:
Beyond the specific industries mentioned, 2,4-Bis(trifluoroMethyl)-6-nitroaniline is a versatile raw material in the broader chemical product manufacturing domain. Its chemical properties allow it to be a component in the production of a wide array of specialty chemicals for diverse applications.

Upstream product

• 654-55-7 2-chloro-1-nitro-3,5-bis-trifluoromethyl-benzene 
• 367-71-5 2,4-bis(trifluoromethyl)aniline 

Downstream Products

• 367-65-7 3,5-bis(trifluoromethyl)-1,2-benzenediamine 

Relevant academic research and scientific papers

Synthesis and structure-activity relationships of substituted 1,4- dihydroquinoxaline-2,3-diones: Antagonists of N-methyl-D-aspartate (NMDA) receptor glycine sites and non-NMDA glutamate receptors

A series of mono-, di-, tri-, and tetrasubstituted 1,4- dihydroquinoxaline-2,3-diones (QXs) were synthesized and evaluated as antagonists at N-methyl-D-aspartate (NMDA)/glycine sites and α-amino-3- hydroxy-5-methylisoxazole-4-propionic acid-preferring non-NMDA receptors. Antagonist potencies were measured by electrical assays in Xenopus oocytes expressing rat whole brain poly(A)+ RNA. Trisubstituted QXs 17a (ACEA 1021), 17b (ACEA 1031), 24a, and 27, containing a nitro group in the 5 position and halogen in the 6 and 7 positions, displayed high potency (K(b) ~ 6-8 nM) at the glycine site, moderate potency at non-NMDA receptors (K(b) = 0.9-1.5 μM), and the highest (120-250-fold) selectivity in favor of glycine site antagonism over non-NMDA receptors. Tetrasubstituted QXs 17d,e were more than 100-fold weaker glycine site antagonists than the corresponding trisubstituted QXs with F being better tolerated than Cl as a substituent at the 8 position. Di- and monosubstituted QXs showed progressively weaker antagonism compared to trisubstituted analogues. For example, removal of the 5-nitro group of 17a results in a ~100-fold decrease in potency (10a,b,z), while removal of both halogens from 17a results in a ~3000-fold decrease in potency (10v). In terms of steady-state inhibition, most QX substitution patterns favor antagonism at NMDA/glycine sites over antagonism at non-NMDA receptors. Among the QXs tested, only 17i was slightly selective for non- NMDA receptors.