32003-36-4

Usage

InChI:InChI=1/C3H5N3OS/c4-6-3-5-2(7)1-8-3/h1,4H2,(H,5,6,7)

Upstream product

• 141-84-4 2-thioxo-4-thiazolidinone 
• 4015-58-1 monochloroacetic acid anhydride 
• 4346-94-5 thiosemicarbazide hydrochloride 
• 79-19-6 thiosemicarbazide 
• 79-11-8 chloroacetic acid 

Downstream Products

• 23969-11-1 benzaldehyde (4-oxo-thiazolidin-2-ylidene)-hydrazone 
• 904-60-9 5-[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-2-{N'-[1-(4-chloro-phenyl)-meth-(E)-ylidene]-hydrazino}-thiazol-4-one 
• 1627-70-9 5-[1-Phenyl-meth-(E)-ylidene]-2-{N'-[1-phenyl-meth-(E)-ylidene]-hydrazino}-thiazol-4-one 
• 264195-71-3 2-hydrazino-7-(4-nitro-phenyl)-5-oxo-5H-pyrano[2,3-d]thiazole-6-carbothioic acid amide 
• 264195-72-4 2-hydrazino-7-(4-methoxy-phenyl)-5-oxo-5H-pyrano[2,3-d]thiazole-6-carbothioic acid amide 
• 264195-81-5 5-[1-(4-Nitro-phenyl)-meth-(Z)-ylidene]-2-{N'-[1-(4-nitro-phenyl)-meth-(E)-ylidene]-hydrazino}-thiazol-4-one 
• 36951-49-2 4-methoxy-benzaldehyde [5-(4-methoxy-benzylidene)-4-oxo-thiazolidin-2-ylidene]-hydrazone 

Relevant academic research and scientific papers

One-pot synthesis of some nitrogen and sulfur heterocycles using thiosemicarbazide under microwave irradiation in a solventless system

A thiazolon, triazines, and triazinones were synthesized under microwave irradiation in a, solventless system in a very short time and in excellent yields. Copyright Taylor & Francis LLC.

Cyclododecanone as a recyclable protecting group for the synthesis of highly functionalized 3-amino-2-thiohydantoins from conventional starting materials

A simple and efficient approach has been developed for the synthesis of highly substituted 3-amino-2-thiohydantoins using cyclododecanone as a protecting group and thiosemicarbazide, chloroacetic acid and substituted benzaldehyde as reactants. This high yielding (79-96%) protocol is a milder alternative to the traditional method that uses unprotected thiosemicarbazide. It was identified that the preferred pathway is the deprotection of 3-amino-2-thiohydantoins followed by the attack of chloroacetic acid on a secondary nitrogen with subsequent formation of the Knoevenagel product and its reaction with imine leading to the final product. The Royal Society of Chemistry.