32018-31-8

Upstream product

• 30314-44-4 2,2-dimethyl-1-(4-methylphenyl)-1-propanone 
• 104-82-5 4-Methylbenzyl chloride 
• 69001-49-6 α,α-dibromo-4-pivaloyl toluene 
• 62985-52-8 ethyl 4-(2,2-dimethylpropanoyl)benzoate 
• 24797-40-8 4-methyl-1-(2,2-dimethylpropyl)benzene 
• 65687-52-7 4-(2,2-dimethylpropyl)benzoic acid 

Downstream Products

• 220764-79-4 methyl 4-(2,2-dimethyl-1-oxopropyl)benzoate 
• 139681-39-3 4-(2,2-dimethyl-1-oxopropyl)-benzoyl chloride 
• 163089-77-8 4-carboxy-α-(1,1-dimethylethyl)benzenemethanol 
• 220764-81-8 4-((R)-1-Hydroxy-2,2-dimethyl-propyl)-benzoic acid methyl ester 
• 167760-01-2 4-(2,2-dimethyl-1-oxopropyl)-benzamide 
• 139681-44-0 4-(2,2-dimethyl-1-oxopropyl)-N-hydroxybenzamide 
• 157465-47-9 4-(2,2-dimethyl-1-oxopropyl)-N-(1-methylethoxy)benzamide 
• 220764-73-8 4-(2,2-dimethyl-1-oxopropyl)-N-(2-chloroethyl)benzamide 
• 157465-51-5 4-(2,2-dimethyl-1-oxopropyl)-N-(2-methoxyethoxy)benzamide 
• 1027022-75-8 4-(2,2-dimethyl-propionyl)-N-(2-hydroxy-ethyl)-benzamide 
• 157465-48-0 4-(2,2-dimethyl-1-oxopropyl)-N-(2-propenyloxy)benzamide 
• 139681-41-7 4-(2,2-dimethyl-1-oxopropyl)-N-(2-hydroxyethoxy)benzamide 
• 157465-55-9 1,1-dimethylethyl 4-<<<4-(2,2-dimethyl-1-oxopropyl)benzoyl>amino>oxy>butanoate 
• 220764-67-0 (S)-2-[4-(2,2-Dimethyl-propionyl)-benzoylamino]-3-phenyl-propionic acid 

Relevant academic research and scientific papers

NOVEL IMIDE DERIVATIVES AND USE THEREOF AS MEDICINE

Provided is a novel low-molecular-weight compound that suppresses production of induction type MMPs, particularly MMP-9, rather than production of hemostatic type MMP-2. The present invention relates to a compound represented by the following formula (I): wherein each symbol is as described in the DESCRIPTION. The compound has a selective MMP-9 production suppressive action, and is useful as a drug for the prophylaxis and/or treatment of autoimmune diseases such as rheumatoid arthritis and the like, inflammatory bowel diseases (ulcerative colitis, Crohn's disease) or osteoarthritis.

DIPHENYL SUBSTITUTED ALKANES

The instant invention provides compounds of Formula (I), which are 5-lipoxygenase activating protein inhibitors. Compounds of Formula (I) are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.

Hypoglycemic prodrugs of 4-(2,2-dimethyl-1-oxopropyl)benzoic acid

SAH 51-641 (1) is a potent hypoglycemic agent, which acts by inhibiting hepatic gluconeogenesis. It is a prodrug of 4-(2,2-dimethyl-1- oxopropyl)benzoic acid (2) and 4-(2,2-dimethyl-1-hydroxypropyl)benzoic acid (3), which sequester coenzyme A (CoA) in the

Dibromination process

The α,α-dibromo-substituted or unsubstituted-4-pivaloyl toluenes, e.g., α,α-dibromo-4-pivaloyl toluene, are prepared by bromination of a corresponding p-pivaloyl toluene with liquid bromine at a temperature of at least 125° C.