220764-79-4Relevant academic research and scientific papers
Copper-catalyzed hydrosilylation with a bowl-shaped phosphane ligand: Preferential reduction of a bulky ketone in the presence of an aldehyde
Fujihara, Tetsuaki,Semba, Kazuhiko,Terao, Jun,Tsuji, Yasushi
supporting information; experimental part, p. 1472 - 1476 (2010/05/02)
Chemical Equation Presented Hollywood bowl: A highly active copper catalyst with a bowl-shaped phosphane (bsp) ligand was used in the hydrosilylation reaction of bulky ketones. The preferential reduction of a bulky ketone in the presence of an unprotected aldehyde is unprecedented.
Convenient preparation of polyfunctional aryl magnesium reagents by a direct magnesium insertion in the presence of LiCl
Piller, Fabian M.,Appukkuttan, Prasad,Gavryushin, Andrei,Helm, Matthew,Knochel, Paul
supporting information; experimental part, p. 6802 - 6806 (2009/04/06)
(Chemical Equation Presented) In the footsteps of Victor Grignard: The simple LiCl-mediated insertion of magnesium into aryl chlorides and bromides at moderate temperatures leads to functionalized organomagnesium reagents (see scheme). An unprecedented range of functional groups may be present in the substrates (e.g. CN, CO2R, OTs, OBoc; Ts=p-toluenesulfonyl, Boc=tert-butylcarbonyloxy).
Hypoglycemic prodrugs of 4-(2,2-dimethyl-1-oxopropyl)benzoic acid
Aicher, Thomas D.,Bebernitz, Gregory R.,Bell, Philip A.,Brand, Leonard J.,Dain, Jeremy G.,Deems, Rhonda,Fillers, William S.,Foley, James E.,Knorr, Douglas C.,Nadelson, Jeffrey,Otero, Dario A.,Simpson, Ronald,Strohschein, Robert J.,Young, Douglas A.
, p. 153 - 163 (2007/10/03)
SAH 51-641 (1) is a potent hypoglycemic agent, which acts by inhibiting hepatic gluconeogenesis. It is a prodrug of 4-(2,2-dimethyl-1- oxopropyl)benzoic acid (2) and 4-(2,2-dimethyl-1-hydroxypropyl)benzoic acid (3), which sequester coenzyme A (CoA) in the
